SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4woj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ALA A 352
ASP A  26
SER A  24
GLU A 353
ASP A 112
 None
 1.39A 1dy4A-4wojA:
undetectable		 1dy4A-4wojA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_2
(ADENOSINE KINASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 4 SER A  71
LEU A  63
TYR A  77
GLY A   5
 None
 1.31A 1liiA-4wojA:
3.6		 1liiA-4wojA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 ASP A  26
ASP A  28
LYS A 363
 None
 0.91A 1lqtB-4wojA:
2.3		 1lqtB-4wojA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 ASP A 104
ASP A 129
LYS A 247
 None
 0.90A 1lqtB-4wojA:
2.3		 1lqtB-4wojA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 ASP A  26
ASP A  28
LYS A 363
 None
 0.94A 1lquB-4wojA:
2.6		 1lquB-4wojA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 ASP A 104
ASP A 129
LYS A 247
 None
 0.90A 1lquB-4wojA:
2.6		 1lquB-4wojA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 ARG A 357
ARG A 356
ILE A  95
 None
 0.77A 1uobA-4wojA:
undetectable		 1uobA-4wojA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 5 LEU A 348
ASP A 345
GLY A 166
ALA A 352
 None
 0.88A 2aohA-4wojA:
undetectable		 2aohA-4wojA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		5 / 11 ILE A 328
ILE A 284
GLY A 146
LEU A 278
PHE A 338
 None
 1.19A 2azyA-4wojA:
undetectable		 2azyA-4wojA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 SER A 271
TYR A 161
HIS A 270
 None
 0.77A 2r2vD-4wojA:
undetectable		 2r2vD-4wojA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		5 / 11 LEU A 274
VAL A 156
ILE A 291
VAL A 153
ILE A 255
 None
 1.17A 2uxoB-4wojA:
undetectable		 2uxoB-4wojA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 5 LEU A 148
GLY A 146
ILE A 323
VAL A 298
 None
 0.89A 3wriA-4wojA:
undetectable		 3wriA-4wojA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 5 LEU A 148
GLY A 146
ILE A 323
VAL A 298
 None
 0.89A 3wriB-4wojA:
undetectable		 3wriB-4wojA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 5 LEU A 148
GLY A 146
ILE A 323
VAL A 298
 None
 0.84A 3wrkA-4wojA:
undetectable		 3wrkA-4wojA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 6 THR A  33
GLY A   5
ARG A  10
ILE A   7
 None
None
SO4  A 402 (-3.1A)
None
 0.71A 4ac9C-4wojA:
4.8		 4ac9C-4wojA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 6 THR A  33
GLY A   5
ARG A  10
ILE A   7
 None
None
SO4  A 402 (-3.1A)
None
 0.73A 4acaC-4wojA:
undetectable		 4acaC-4wojA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 6 THR A  33
GLY A   5
ARG A  10
ILE A   7
 None
None
SO4  A 402 (-3.1A)
None
 0.75A 4acbC-4wojA:
2.4		 4acbC-4wojA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 5 ILE A 131
VAL A 110
CYH A  72
HIS A  82
 None
 1.38A 4rzvA-4wojA:
undetectable		 4rzvA-4wojA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ILE A  30
PHE A  93
GLY A   5
ILE A 361
ASP A  67
 None
 0.96A 5e72A-4wojA:
3.0		 5e72A-4wojA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 ALA A  98
GLN A  73
THR A  78
 None
 0.67A 5n0oA-4wojA:
undetectable		 5n0oA-4wojA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 VAL A 264
TYR A 161
GLN A 162
 None
 0.59A 5qgkA-4wojA:
undetectable		 5qgkA-4wojA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 VAL A 264
TYR A 161
GLN A 162
 None
 0.57A 5qgrA-4wojA:
undetectable		 5qgrA-4wojA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		3 / 3 VAL A 264
TYR A 161
GLN A 162
 None
 0.58A 5qgtA-4wojA:
undetectable		 5qgtA-4wojA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 LEU A 249
THR A 251
PHE A 338
VAL A 276
ILE A 144
 None
 1.28A 5tuiB-4wojA:
undetectable		 5tuiB-4wojA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		5 / 12 ALA A 143
LEU A 245
ILE A 255
VAL A 276
ASP A 258
 None
 1.18A 5vlmG-4wojA:
undetectable		 5vlmG-4wojA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 4 ASP A 104
SER A 107
ASP A 129
HIS A  82
 None
 1.20A 5wyqB-4wojA:
undetectable		 5wyqB-4wojA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 4 ASP A 106
SER A 107
ASP A 129
HIS A  82
 None
 0.94A 5wyqB-4wojA:
undetectable		 5wyqB-4wojA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE
(Francisella
tularensis) 		4 / 7 VAL A  16
LEU A 321
GLY A 319
GLY A 166
 None
 0.72A 6eu9D-4wojA:
undetectable		 6eu9D-4wojA:
11.11