SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 143
LEU A 177
GLY A 176
TRP A 171
LEU A 146
 SO4  A 302 (-4.6A)
None
None
None
SO4  A 302 (-3.5A)
 1.22A 2w8yA-4wopA:
undetectable		 2w8yA-4wopA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 133
ALA A 134
ALA A 132
VAL A  33
ILE A  31
 None
 1.09A 3falA-4wopA:
undetectable		 3falA-4wopA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 10 THR A   7
LEU A 156
VAL A 161
LEU A 124
VAL A 122
 None
 1.21A 3tbgC-4wopA:
undetectable		 3tbgC-4wopA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 197
GLY A 199
ALA A 200
ASP A 207
 None
CTP  A 301 (-3.0A)
CTP  A 301 (-3.6A)
None
 0.72A 3ur0B-4wopA:
undetectable		 3ur0B-4wopA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 200
LEU A  56
PHE A 208
SER A 170
VAL A   6
 CTP  A 301 (-3.6A)
None
None
CTP  A 301 ( 4.2A)
None
 1.27A 4claA-4wopA:
undetectable		 4claA-4wopA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  21
PHE A 216
ALA A 194
LEU A 196
 None
None
None
CTP  A 301 ( 4.4A)
 0.85A 4du2A-4wopA:
undetectable		 4du2A-4wopA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  21
PHE A 216
ALA A 194
LEU A 196
 None
None
None
CTP  A 301 ( 4.4A)
 0.84A 4du2B-4wopA:
undetectable		 4du2B-4wopA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 167
LEU A 136
VAL A 138
LEU A  22
VAL A   6
 None
 0.99A 4e3hA-4wopA:
undetectable		 4e3hA-4wopA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 215
LEU A 196
VAL A 192
GLY A 165
LEU A 224
 None
CTP  A 301 ( 4.4A)
None
None
None
 1.07A 5x24A-4wopA:
undetectable		 5x24A-4wopA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wop ATP-DEPENDENT
DETHIOBIOTIN
SYNTHETASE BIOD
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  38
GLY A  64
LEU A  98
VAL A 107
 None
 0.99A 5x80A-4wopA:
undetectable
5x80B-4wopA:
undetectable		 5x80A-4wopA:
21.74
5x80B-4wopA:
21.74