SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4woq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		3 / 3 GLU A  84
ILE A  85
ARG A 228
 None
 0.74A 1cd2A-4woqA:
undetectable		 1cd2A-4woqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		4 / 8 SER A 115
ALA A 113
ILE A  88
ASN A 142
 None
 1.12A 1pnlA-4woqA:
undetectable
1pnlB-4woqA:
undetectable		 1pnlA-4woqA:
20.52
1pnlB-4woqA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		4 / 4 VAL A 117
THR A 118
VAL A 155
GLY A 154
 None
 1.18A 2p2fB-4woqA:
undetectable		 2p2fB-4woqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 12 LEU A  22
ILE A  32
GLY A  36
ILE A  76
LEU A 269
 None
 1.22A 3uj7B-4woqA:
undetectable		 3uj7B-4woqA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		8 / 10 ILE A 149
LEU A 152
THR A 177
GLY A 199
ASP A 201
GLU A 202
GLY A 217
SER A 218
 None
 0.39A 4bwlC-4woqA:
42.9		 4bwlC-4woqA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		4 / 8 PRO A 119
ASN A  95
GLN A  90
ILE A 136
 None
 1.08A 4iilA-4woqA:
undetectable		 4iilA-4woqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 12 ASN A  44
ILE A  41
ILE A  40
ALA A  21
VAL A  24
 None
 1.13A 4nkvC-4woqA:
undetectable		 4nkvC-4woqA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 6 SER A 158
LEU A 159
ASP A 160
TYR A 182
LEU A 183
 None
2KT  A 401 ( 4.4A)
None
2KT  A 401 (-3.8A)
2KT  A 401 ( 4.0A)
 0.16A 4wozA-4woqA:
51.6
4wozB-4woqA:
52.0		 4wozA-4woqA:
100.00
4wozB-4woqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		4 / 5 LEU A 159
ASP A 160
TYR A 182
LEU A 183
 2KT  A 401 ( 4.4A)
None
2KT  A 401 (-3.8A)
2KT  A 401 ( 4.0A)
 0.11A 4wozF-4woqA:
51.9
4wozH-4woqA:
52.5		 4wozF-4woqA:
100.00
4wozH-4woqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 12 SER A 158
PHE A 191
PHE A 176
THR A 153
GLY A 154
 None
 1.49A 4zjlA-4woqA:
undetectable		 4zjlA-4woqA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 12 LEU A  22
ILE A 114
LEU A 144
GLY A  92
GLY A  60
 None
 1.05A 5d4uA-4woqA:
undetectable		 5d4uA-4woqA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		4 / 6 GLY A  56
ASP A 201
ILE A  18
TYR A 147
 None
 1.09A 5iwuA-4woqA:
undetectable		 5iwuA-4woqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 12 ASN A 250
GLN A 229
THR A 177
GLY A 217
THR A 219
 None
 1.39A 5oj0A-4woqA:
undetectable		 5oj0A-4woqA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		5 / 12 ILE A 129
LEU A 165
GLY A  92
ALA A 116
LEU A 144
 None
 0.97A 5zwrA-4woqA:
undetectable		 5zwrA-4woqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4woq N-ACETYLNEURAMINATE
LYASE
(Clostridioides
difficile) 		4 / 6 THR A 234
PRO A 206
GLN A 246
ILE A 239
 None
 1.16A 6ef6A-4woqA:
undetectable		 6ef6A-4woqA:
21.07