SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 9 LEU A 595
VAL A 603
GLY A 693
PRO A 694
LEU A 741
 3SM  A 901 (-3.9A)
3SM  A 901 ( 4.4A)
3SM  A 901 (-3.0A)
3SM  A 901 (-4.3A)
3SM  A 901 (-4.1A)
 0.44A 1xbbA-4wovA:
28.1		 1xbbA-4wovA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 12 LEU A 722
LEU A 757
GLY A 733
CYH A 783
ASN A 734
ALA A 780
 None
None
None
None
SO4  A 903 (-4.1A)
None
 1.36A 2bm9C-4wovA:
undetectable		 2bm9C-4wovA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		5 / 12 LEU A 722
LEU A 757
GLY A 733
CYH A 783
ALA A 780
 None
 1.13A 2bm9D-4wovA:
undetectable		 2bm9D-4wovA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 4 LEU A 805
PRO A 814
LEU A 833
ARG A 832
 None
 1.42A 2hrcA-4wovA:
undetectable		 2hrcA-4wovA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 11 LEU A 595
VAL A 603
THR A 687
TYR A 689
GLY A 693
LEU A 741
 3SM  A 901 (-3.9A)
3SM  A 901 ( 4.4A)
3SM  A 901 ( 4.6A)
3SM  A 901 (-3.2A)
3SM  A 901 (-3.0A)
3SM  A 901 (-4.1A)
 0.76A 3g0fA-4wovA:
21.0		 3g0fA-4wovA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		6 / 10 LEU A 595
VAL A 603
THR A 687
TYR A 689
GLY A 693
LEU A 741
 3SM  A 901 (-3.9A)
3SM  A 901 ( 4.4A)
3SM  A 901 ( 4.6A)
3SM  A 901 (-3.2A)
3SM  A 901 (-3.0A)
3SM  A 901 (-4.1A)
 0.69A 3g0fB-4wovA:
22.5		 3g0fB-4wovA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 7 THR A 658
HIS A 732
ASN A 739
PHE A 655
 None
None
SO4  A 903 (-3.9A)
None
 1.40A 4awuA-4wovA:
undetectable		 4awuA-4wovA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 6 LEU A 699
LEU A 695
ILE A 755
THR A 803
 None
 0.95A 4do3B-4wovA:
undetectable		 4do3B-4wovA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FVQ_A_ACTA903_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens) 		4 / 4 ASN A 734
CYH A 736
ARG A 775
TRP A 778
 SO4  A 903 (-4.1A)
None
None
None
 0.68A 4fvqA-4wovA:
37.0		 4fvqA-4wovA:
40.94