SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 10 LEU A 180
LEU A 178
LEU A 198
GLU A 194
LEU A 202
 None
 1.37A 1ie4A-4wp0A:
undetectable
1ie4C-4wp0A:
undetectable		 1ie4A-4wp0A:
14.75
1ie4C-4wp0A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 5 PHE A 347
LEU A 422
PHE A 366
MET A 370
 None
 1.17A 1wrkB-4wp0A:
undetectable		 1wrkB-4wp0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 PHE A 347
LEU A 422
PHE A 366
VAL A 377
 None
 1.08A 1wrlA-4wp0A:
undetectable
1wrlB-4wp0A:
undetectable		 1wrlA-4wp0A:
13.23
1wrlB-4wp0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 4 VAL A 381
LEU A 154
ILE A 321
LEU A 324
 None
 1.05A 2byoA-4wp0A:
undetectable		 2byoA-4wp0A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 8 MET A 131
TYR A 128
ALA A 107
ALA A 103
 None
 0.99A 2wx2B-4wp0A:
undetectable		 2wx2B-4wp0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 MET A 131
PHE A 108
TYR A 128
ALA A 107
ALA A 103
 None
 0.99A 2x2nD-4wp0A:
undetectable		 2x2nD-4wp0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 GLY A 188
ASN A 184
SER A 157
VAL A 381
 None
 0.78A 3a2qA-4wp0A:
undetectable		 3a2qA-4wp0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 6 ARG A 300
PHE A 306
PHE A  79
PHE A  80
 None
 1.29A 3af3A-4wp0A:
undetectable		 3af3A-4wp0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 8 MET A 131
TYR A 128
ALA A 107
ALA A 103
 None
 0.81A 3khmA-4wp0A:
undetectable		 3khmA-4wp0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 5 LEU A 329
GLY A 328
PHE A 347
PHE A 366
 None
 1.18A 3smtA-4wp0A:
undetectable		 3smtA-4wp0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 PHE A  40
PHE A 309
ALA A 251
THR A 252
VAL A 402
 None
 1.09A 4g1bA-4wp0A:
undetectable		 4g1bA-4wp0A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 6 ILE A 229
THR A 239
VAL A 190
SER A 231
 None
 0.90A 4iaqA-4wp0A:
undetectable		 4iaqA-4wp0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 7 PHE A  80
LEU A  84
GLU A 214
THR A 248
 None
None
None
LLP  A 247 ( 4.3A)
 0.98A 4wnvD-4wp0A:
undetectable		 4wnvD-4wp0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		4 / 8 LEU A 202
GLU A 166
LEU A 162
ILE A 121
 None
 0.97A 5mzjA-4wp0A:
undetectable		 5mzjA-4wp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 9 VAL A 179
GLY A 243
VAL A 215
GLU A 214
GLY A 257
 None
None
LLP  A 247 ( 4.7A)
None
None
 1.35A 5zniA-4wp0A:
undetectable		 5zniA-4wp0A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1
(Homo
sapiens) 		5 / 12 ILE A 397
VAL A 179
LEU A 104
GLY A  34
PHE A 124
 None
 1.24A 6a7pA-4wp0A:
undetectable		 6a7pA-4wp0A:
22.11