SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4wp3 MA1120
(Mycobacterium
avium) 		4 / 4 ILE A  81
LEU A 124
VAL A 142
ILE A 140
 None
 0.57A 1fm6D-4wp3A:
undetectable		 1fm6D-4wp3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wp3 MA1120
(Mycobacterium
avium) 		4 / 7 ARG A 143
ALA A  36
ARG A 168
ASP A  61
 None
 1.21A 2e5dA-4wp3A:
undetectable
2e5dB-4wp3A:
undetectable		 2e5dA-4wp3A:
16.95
2e5dB-4wp3A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wp3 MA1120
(Mycobacterium
avium) 		4 / 7 ASP A  61
ARG A 143
ALA A  36
ARG A 168
 None
 1.27A 2e5dA-4wp3A:
undetectable
2e5dB-4wp3A:
undetectable		 2e5dA-4wp3A:
16.95
2e5dB-4wp3A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4wp3 MA1120
(Mycobacterium
avium) 		5 / 9 GLY A 106
ILE A 144
VAL A 109
ILE A  57
VAL A  56
 None
 1.27A 2nnhB-4wp3A:
undetectable		 2nnhB-4wp3A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4wp3 MA1120
(Mycobacterium
avium) 		5 / 12 MET A 165
ASN A 162
VAL A 163
GLY A 145
ILE A 178
 None
 1.37A 4xucA-4wp3A:
undetectable		 4xucA-4wp3A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4wp3 MA1120
(Mycobacterium
avium) 		5 / 12 ILE A 194
PHE A 196
ALA A 187
ASP A 186
ILE A 146
 None
 1.09A 6dwnD-4wp3A:
undetectable		 6dwnD-4wp3A:
17.39