SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		5 / 9 VAL A 266
LEU A 289
PHE A 242
MET A 246
SER A 250
 None
 1.38A 1wrkA-4wp6A:
undetectable
1wrkB-4wp6A:
undetectable		 1wrkA-4wp6A:
19.53
1wrkB-4wp6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 215
LEU A 214
LEU A 217
ASN A 271
LEU A 292
 None
 1.21A 3ndvA-4wp6A:
undetectable
3ndvB-4wp6A:
undetectable		 3ndvA-4wp6A:
17.63
3ndvB-4wp6A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 217
ASN A 271
LEU A 292
LEU A 215
LEU A 214
 None
 1.20A 3ndvC-4wp6A:
undetectable
3ndvD-4wp6A:
undetectable		 3ndvC-4wp6A:
17.63
3ndvD-4wp6A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		4 / 6 LEU A 245
SER A 241
ALA A 238
LEU A 200
 None
 1.06A 3rd0A-4wp6A:
undetectable		 3rd0A-4wp6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		5 / 12 TYR A 253
LEU A 286
LEU A 268
LEU A 200
LEU A 204
 None
 1.14A 3vw7A-4wp6A:
undetectable		 3vw7A-4wp6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		4 / 8 ARG A 206
ASP A 216
SER A 267
ALA A 219
 None
 1.16A 4lv9A-4wp6A:
3.2
4lv9B-4wp6A:
2.4		 4lv9A-4wp6A:
17.04
4lv9B-4wp6A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE A 312
ARG A 291
ALA A 265
LEU A 292
 None
 1.03A 4xk8A-4wp6A:
undetectable		 4xk8A-4wp6A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		4 / 4 ASN A 297
LEU A 299
SER A 295
LEU A 318
 None
 1.39A 5kb5A-4wp6A:
undetectable		 5kb5A-4wp6A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4wp6 MRNA EXPORT PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ILE A 263
TYR A 208
LEU A 214
ARG A 291
 None
 0.98A 6f6jA-4wp6A:
undetectable		 6f6jA-4wp6A:
undetectable