SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 GLU A 193
ARG A 189
LEU A  18
GLU A  21
 None
 0.82A 1cmaA-4wpgA:
undetectable
1cmaB-4wpgA:
undetectable		 1cmaA-4wpgA:
21.13
1cmaB-4wpgA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 SER A 100
THR A 101
GLU A 135
GLY A 134
 None
 1.26A 1icrA-4wpgA:
undetectable
1icrB-4wpgA:
undetectable		 1icrA-4wpgA:
22.59
1icrB-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 GLU A 135
GLY A 134
SER A 100
THR A 101
 None
 1.25A 1icrA-4wpgA:
undetectable
1icrB-4wpgA:
undetectable		 1icrA-4wpgA:
22.59
1icrB-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 PHE A 163
GLU A  14
GLY A 155
PHE A 277
 None
 1.16A 1icuA-4wpgA:
undetectable
1icuB-4wpgA:
undetectable		 1icuA-4wpgA:
22.59
1icuB-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 SER A 100
THR A 101
GLU A 135
GLY A 134
 None
 1.25A 1icvC-4wpgA:
undetectable
1icvD-4wpgA:
undetectable		 1icvC-4wpgA:
22.59
1icvD-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 GLU A 135
GLY A 134
SER A 100
THR A 101
 None
 1.25A 1icvC-4wpgA:
undetectable
1icvD-4wpgA:
undetectable		 1icvC-4wpgA:
22.59
1icvD-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 GLU A 135
GLY A 134
SER A 100
THR A 101
 None
 1.24A 1kqbA-4wpgA:
undetectable
1kqbB-4wpgA:
undetectable		 1kqbA-4wpgA:
23.00
1kqbB-4wpgA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 SER A  82
ASN A  84
ILE A  36
GLU A  75
 None
 0.97A 1meiA-4wpgA:
undetectable		 1meiA-4wpgA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 PHE A 161
ASN A 160
GLY A 155
PHE A 277
 None
 0.90A 1ykiA-4wpgA:
undetectable
1ykiB-4wpgA:
undetectable		 1ykiA-4wpgA:
22.59
1ykiB-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 PHE A 277
PHE A 161
ASN A 160
GLY A 155
 None
 0.93A 1ykiA-4wpgA:
undetectable
1ykiB-4wpgA:
undetectable		 1ykiA-4wpgA:
22.59
1ykiB-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 PHE A 161
ASN A 160
GLY A 155
PHE A 277
 None
 0.89A 1ykiC-4wpgA:
undetectable
1ykiD-4wpgA:
undetectable		 1ykiC-4wpgA:
22.59
1ykiD-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 PHE A 277
PHE A 161
ASN A 160
GLY A 155
 None
 0.93A 1ykiC-4wpgA:
undetectable
1ykiD-4wpgA:
undetectable		 1ykiC-4wpgA:
22.59
1ykiD-4wpgA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 ALA A 192
LEU A 191
MET A 195
ILE A  36
 None
 0.92A 3cldB-4wpgA:
undetectable		 3cldB-4wpgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 GLN A 167
THR A 164
THR A 176
HIS A 172
 None
 1.09A 3g1uC-4wpgA:
4.8		 3g1uC-4wpgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 7 GLU A 193
GLU A  14
TYR A  17
GLU A  21
 None
 1.14A 4mi4B-4wpgA:
undetectable
4mi4C-4wpgA:
undetectable		 4mi4B-4wpgA:
21.40
4mi4C-4wpgA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 7 GLU A 193
GLU A  14
TYR A  17
GLU A  21
 None
 1.14A 4mi4A-4wpgA:
undetectable
4mi4C-4wpgA:
undetectable		 4mi4A-4wpgA:
21.40
4mi4C-4wpgA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 8 GLU A 193
GLU A  14
TYR A  17
GLU A  21
 None
 1.17A 4mj8B-4wpgA:
undetectable
4mj8C-4wpgA:
undetectable		 4mj8B-4wpgA:
21.84
4mj8C-4wpgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		4 / 7 GLU A 193
GLU A  14
TYR A  17
GLU A  21
 None
 1.02A 4mj8C-4wpgA:
undetectable		 4mj8C-4wpgA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		5 / 9 ASP A  30
VAL A  31
ALA A  58
ILE A  77
ILE A  36
 None
 0.68A 4oknB-4wpgA:
6.2		 4oknB-4wpgA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 ALA A  59
THR A  61
THR A 150
GLY A 134
SER A  82
 None
 1.19A 4ypmA-4wpgA:
undetectable		 4ypmA-4wpgA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  18
LEU A  11
THR A  95
ILE A   4
ILE A   2
 None
None
MRD  A 302 (-2.9A)
None
None
 1.09A 5itzB-4wpgA:
6.4		 5itzB-4wpgA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  18
ALA A 192
THR A  95
ILE A   4
ILE A   2
 None
None
MRD  A 302 (-2.9A)
None
None
 0.92A 5xiwD-4wpgA:
6.1		 5xiwD-4wpgA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4wpg DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 TYR A  55
LEU A  15
ILE A   2
THR A 199
LEU A 198
 MPD  A 301 (-4.6A)
None
None
MPD  A 301 ( 3.2A)
None
 1.26A 6djzB-4wpgA:
undetectable		 6djzB-4wpgA:
22.41