SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 ALA A 366
LEU A 131
LEU A 400
LEU A 252
MET A 374
 None
 1.18A 1dtlA-4wpzA:
undetectable		 1dtlA-4wpzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 9 LEU A 363
GLU A 362
ALA A 366
LEU A 148
PRO A 149
 None
HEM  A 503 ( 4.5A)
None
None
None
 1.49A 1mj2A-4wpzA:
undetectable		 1mj2A-4wpzA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 9 LEU A 363
GLU A 362
ALA A 366
LEU A 148
PRO A 149
 None
HEM  A 503 ( 4.5A)
None
None
None
 1.45A 1mjoB-4wpzA:
undetectable		 1mjoB-4wpzA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 GLU A 362
LEU A 358
LEU A 157
GLY A 158
 HEM  A 503 ( 4.5A)
None
None
None
 0.91A 1mt1H-4wpzA:
undetectable
1mt1K-4wpzA:
undetectable		 1mt1H-4wpzA:
15.27
1mt1K-4wpzA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 6 GLU A 362
LEU A 358
LEU A 157
GLY A 158
 HEM  A 503 ( 4.5A)
None
None
None
 0.88A 1n13H-4wpzA:
undetectable
1n13K-4wpzA:
undetectable		 1n13H-4wpzA:
15.27
1n13K-4wpzA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 LEU A 358
LEU A 157
GLY A 158
GLU A 362
 None
None
None
HEM  A 503 ( 4.5A)
 0.91A 1n13G-4wpzA:
undetectable
1n13J-4wpzA:
undetectable		 1n13G-4wpzA:
9.69
1n13J-4wpzA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 THR A 286
THR A 288
VAL A  90
MET A  85
 None
None
HEM  A 503 (-3.8A)
None
 1.12A 1tv8A-4wpzA:
undetectable		 1tv8A-4wpzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 THR A 286
THR A 288
VAL A  90
MET A  85
 None
None
HEM  A 503 (-3.8A)
None
 1.08A 1tv8B-4wpzA:
undetectable		 1tv8B-4wpzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 6 LEU A 210
ARG A 227
THR A 225
LEU A 224
 None
 1.06A 2dysN-4wpzA:
undetectable
2dysW-4wpzA:
undetectable		 2dysN-4wpzA:
21.80
2dysW-4wpzA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 9 ILE A 234
GLY A  91
ASN A  86
GLU A  87
ARG A 227
 None
 1.50A 2pivA-4wpzA:
2.3		 2pivA-4wpzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 LEU A 388
ILE A 394
PRO A 401
VAL A 381
VAL A 141
 None
 1.20A 2po5A-4wpzA:
undetectable		 2po5A-4wpzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 11 LEU A 388
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.25A 2po5B-4wpzA:
undetectable		 2po5B-4wpzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		6 / 12 LEU A 388
ILE A 394
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.30A 2po7A-4wpzA:
undetectable		 2po7A-4wpzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 LEU A 388
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.18A 2qd4A-4wpzA:
undetectable		 2qd4A-4wpzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 LEU A 388
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.29A 2qd4B-4wpzA:
undetectable		 2qd4B-4wpzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 LEU A 127
LEU A 131
ILE A 248
ALA A 366
ARG A 378
 None
 1.22A 2v0mC-4wpzA:
30.0		 2v0mC-4wpzA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 SER A 249
LEU A 127
LEU A 131
ALA A 366
ARG A 378
 None
 1.07A 2v0mC-4wpzA:
30.0		 2v0mC-4wpzA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 6 MET A  48
ARG A 323
PRO A 293
GLY A 289
 None
 1.37A 3aqiA-4wpzA:
undetectable		 3aqiA-4wpzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		3 / 3 ALA A 239
THR A 243
CYH A 353
 HEM  A 503 (-3.4A)
HEM  A 503 (-3.9A)
HEM  A 503 (-2.4A)
 0.60A 3e4eA-4wpzA:
30.2		 3e4eA-4wpzA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		3 / 3 ALA A 239
THR A 243
CYH A 353
 HEM  A 503 (-3.4A)
HEM  A 503 (-3.9A)
HEM  A 503 (-2.4A)
 0.54A 3e4eB-4wpzA:
30.1		 3e4eB-4wpzA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 5 ASN A 143
ASN A 172
HIS A 241
ALA A 245
 None
 1.41A 3frqA-4wpzA:
1.0		 3frqA-4wpzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 ASN A 143
ASN A 172
HIS A 241
ALA A 245
 None
 1.43A 3frqB-4wpzA:
undetectable		 3frqB-4wpzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 THR A 288
THR A 287
THR A 286
ILE A   9
LEU A  26
 None
K  A 501 (-3.5A)
None
None
None
 1.18A 3gwxA-4wpzA:
undetectable		 3gwxA-4wpzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		3 / 3 PRO A 284
LEU A 285
GLN A 247
 None
HEM  A 503 (-4.3A)
HEM  A 503 ( 4.7A)
 0.67A 3hznG-4wpzA:
undetectable
3hznH-4wpzA:
undetectable		 3hznG-4wpzA:
20.60
3hznH-4wpzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		3 / 3 LEU A  22
PRO A  23
LEU A  26
 None
 0.47A 3w1wB-4wpzA:
undetectable		 3w1wB-4wpzA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 6 ARG A 294
HIS A  97
ARG A 101
ILE A 350
 HEM  A 503 (-2.9A)
HEM  A 503 (-3.9A)
HEM  A 503 (-3.8A)
None
 1.42A 5a06A-4wpzA:
undetectable		 5a06A-4wpzA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 11 LEU A  22
VAL A 283
THR A 286
ALA A 319
GLN A 247
 None
None
None
None
HEM  A 503 ( 4.7A)
 1.00A 5o96A-4wpzA:
undetectable
5o96B-4wpzA:
undetectable		 5o96A-4wpzA:
21.80
5o96B-4wpzA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 6 PHE A  64
PRO A 293
VAL A 314
THR A 288
 None
 1.15A 5t7bA-4wpzA:
undetectable		 5t7bA-4wpzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 ILE A 153
LEU A 156
ILE A 230
ALA A 107
 None
 0.88A 6b5vA-4wpzA:
undetectable
6b5vC-4wpzA:
undetectable		 6b5vA-4wpzA:
12.23
6b5vC-4wpzA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 ILE A 153
LEU A 156
ILE A 230
ALA A 107
 None
 0.88A 6b5vC-4wpzA:
undetectable
6b5vD-4wpzA:
undetectable		 6b5vC-4wpzA:
12.23
6b5vD-4wpzA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 7 ALA A 107
ILE A 153
LEU A 156
ILE A 230
 None
 0.88A 6b5vB-4wpzA:
undetectable
6b5vD-4wpzA:
undetectable		 6b5vB-4wpzA:
12.23
6b5vD-4wpzA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 12 LEU A 175
LEU A 237
ILE A 153
VAL A 152
THR A 244
 None
None
None
None
HEM  A 503 (-4.1A)
 1.20A 6debB-4wpzA:
undetectable		 6debB-4wpzA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		5 / 10 LEU A 285
PRO A 284
LEU A  22
ASN A 322
LEU A 344
 HEM  A 503 (-4.3A)
None
None
None
None
 1.42A 6hupD-4wpzA:
1.4
6hupE-4wpzA:
1.3		 6hupD-4wpzA:
12.67
6hupE-4wpzA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wpz CYTOCHROME P450
(Streptomyces
avermitilis) 		4 / 5 LEU A 210
ARG A 227
THR A 225
LEU A 224
 None
 0.86A 6nmpN-4wpzA:
undetectable
6nmpW-4wpzA:
undetectable		 6nmpN-4wpzA:
21.80
6nmpW-4wpzA:
9.39