SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 ALA C 113
VAL C 161
TRP C 160
 None
 0.84A 1grmA-4wq5C:
undetectable		 1grmA-4wq5C:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 ALA C 113
VAL C 161
TRP C 160
 None
 0.84A 1grmB-4wq5C:
undetectable		 1grmB-4wq5C:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 ALA C 113
VAL C 161
TRP C 160
 None
 0.92A 1jo3A-4wq5C:
undetectable		 1jo3A-4wq5C:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 ALA C 113
VAL C 161
TRP C 160
 None
 0.92A 1jo3B-4wq5C:
undetectable		 1jo3B-4wq5C:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 ALA C 113
VAL C 161
TRP C 160
 None
 0.92A 1jo4A-4wq5C:
undetectable		 1jo4A-4wq5C:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 ALA C 113
VAL C 161
TRP C 160
 None
 0.92A 1jo4B-4wq5C:
undetectable		 1jo4B-4wq5C:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		4 / 5 TRP C 124
ALA C 113
LEU C 144
ALA C 114
 None
 1.35A 2jstA-4wq5C:
undetectable
2jstB-4wq5C:
undetectable		 2jstA-4wq5C:
15.42
2jstB-4wq5C:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		3 / 3 LEU C  87
PRO C  88
ARG C   2
 None
 0.59A 2qd5A-4wq5C:
undetectable		 2qd5A-4wq5C:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		5 / 12 ALA C  60
ILE C   6
ARG C 104
LEU C 195
ILE C  45
 None
 1.07A 3k2hB-4wq5C:
undetectable		 3k2hB-4wq5C:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		5 / 12 ILE C  77
LEU C  81
LEU C  53
LEU C  46
ILE C  56
 None
 1.11A 3uvvA-4wq5C:
undetectable		 3uvvA-4wq5C:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4wq5 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAB
(Escherichia
coli) 		4 / 5 THR C  10
HIS C  34
ALA C  12
ASP C   7
 None
ACT  C 301 (-4.6A)
None
None
 1.30A 5mfxA-4wq5C:
undetectable		 5mfxA-4wq5C:
19.40