SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 TYR A  34
GLY A 187
PRO A 188
SER A 131
PHE A 136
 None
None
None
BTB  A 406 (-3.6A)
None
 1.43A 1fdsA-4wqmA:
2.8		 1fdsA-4wqmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 GLY A 208
SER A 209
GLU A 241
ILE A 162
LEU A 113
 None
FAD  A 402 (-3.7A)
None
None
None
 1.26A 1kyvA-4wqmA:
undetectable
1kyvE-4wqmA:
undetectable		 1kyvA-4wqmA:
18.83
1kyvE-4wqmA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 LEU A 113
GLY A 208
SER A 209
GLU A 241
ILE A 162
 None
None
FAD  A 402 (-3.7A)
None
None
 1.27A 1kyvB-4wqmA:
3.4
1kyvC-4wqmA:
3.1		 1kyvB-4wqmA:
18.83
1kyvC-4wqmA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 LEU A 113
GLY A 208
SER A 209
GLU A 241
ILE A 162
 None
None
FAD  A 402 (-3.7A)
None
None
 1.25A 1kyvC-4wqmA:
2.3
1kyvD-4wqmA:
3.4		 1kyvC-4wqmA:
18.83
1kyvD-4wqmA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 LEU A 113
GLY A 208
SER A 209
GLU A 241
ILE A 162
 None
None
FAD  A 402 (-3.7A)
None
None
 1.23A 1kyvD-4wqmA:
3.4
1kyvE-4wqmA:
undetectable		 1kyvD-4wqmA:
18.83
1kyvE-4wqmA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 PHE A 103
VAL A 128
PHE A 118
VAL A 163
LEU A 185
 None
None
None
FAD  A 402 (-3.3A)
None
 1.15A 2ft9A-4wqmA:
undetectable		 2ft9A-4wqmA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 5 VAL A 107
VAL A 108
THR A 182
ARG A 106
 None
 1.16A 3bjwA-4wqmA:
undetectable		 3bjwA-4wqmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 5 VAL A 107
VAL A 108
THR A 182
ARG A 106
 None
 1.17A 3bjwC-4wqmA:
undetectable		 3bjwC-4wqmA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		3 / 3 GLU A 116
SER A 263
VAL A 264
 None
 0.84A 3eeoA-4wqmA:
2.6		 3eeoA-4wqmA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		3 / 3 GLU A 241
SER A 263
VAL A 264
 None
 0.81A 3eeoA-4wqmA:
2.6		 3eeoA-4wqmA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 10 VAL A 260
VAL A 277
TYR A 284
GLY A 235
GLY A 207
 None
 1.08A 3ls4H-4wqmA:
undetectable		 3ls4H-4wqmA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 ILE A 180
LEU A 175
VAL A 163
LEU A 122
ALA A 151
 None
None
FAD  A 402 (-3.3A)
None
None
 1.20A 3ozuA-4wqmA:
12.9		 3ozuA-4wqmA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 PHE A 325
LEU A 194
PHE A 130
ALA A 150
SER A 216
 FAD  A 402 (-3.3A)
None
None
None
None
 1.14A 3tbgD-4wqmA:
undetectable		 3tbgD-4wqmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 PHE A  32
LEU A  84
VAL A  53
PHE A  13
ALA A  15
 None
 1.37A 3u9fG-4wqmA:
undetectable
3u9fH-4wqmA:
undetectable		 3u9fG-4wqmA:
18.51
3u9fH-4wqmA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		3 / 3 SER A  38
GLY A  39
GLN A  77
 FAD  A 402 (-3.4A)
FES  A 401 (-3.5A)
FAD  A 402 ( 4.7A)
 0.65A 3v4tH-4wqmA:
undetectable		 3v4tH-4wqmA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 9 ALA A 223
GLY A 225
LEU A 221
ASN A 254
ILE A 230
 None
 1.39A 3wdmA-4wqmA:
2.3		 3wdmA-4wqmA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 5 ILE A 211
ALA A 244
MET A 117
ARG A 111
 None
 1.30A 4ac9B-4wqmA:
4.4
4ac9C-4wqmA:
4.5		 4ac9B-4wqmA:
22.05
4ac9C-4wqmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 10 GLY A  62
ALA A  43
GLY A  42
CYH A  36
CYH A  44
 BTB  A 408 (-4.5A)
None
FES  A 401 (-3.9A)
FES  A 401 ( 2.3A)
FES  A 401 (-2.3A)
 1.11A 4c5lC-4wqmA:
4.8		 4c5lC-4wqmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 PHE A 233
ILE A 205
GLY A 207
MET A 214
ALA A 212
 None
None
None
None
FAD  A 402 (-3.3A)
 1.28A 4eb4A-4wqmA:
undetectable		 4eb4A-4wqmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 PHE A 233
ILE A 205
GLY A 207
MET A 214
ALA A 212
 None
None
None
None
FAD  A 402 (-3.3A)
 1.28A 4eb4B-4wqmA:
undetectable		 4eb4B-4wqmA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 6 PHE A 326
ILE A 302
PRO A 298
PHE A 325
 None
None
None
FAD  A 402 (-3.3A)
 0.88A 4fgkA-4wqmA:
3.0		 4fgkA-4wqmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 4 VAL A 203
ILE A 320
ASN A 313
VAL A 305
 None
 1.17A 5ajqA-4wqmA:
undetectable		 5ajqA-4wqmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		3 / 3 ASN A  37
SER A  23
ARG A 102
 None
 0.87A 5b2qA-4wqmA:
undetectable		 5b2qA-4wqmA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 12 LEU A   9
ALA A  25
LEU A  26
ILE A  46
LEU A  56
 None
 1.23A 5ljcA-4wqmA:
undetectable		 5ljcA-4wqmA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 6 GLU A 239
ALA A 240
LEU A 242
TYR A 272
 None
 1.12A 5phhA-4wqmA:
undetectable		 5phhA-4wqmA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		5 / 9 SER A 149
GLY A 210
ALA A 212
CYH A 296
GLY A 297
 FAD  A 402 (-3.0A)
None
FAD  A 402 (-3.3A)
None
None
 0.51A 5vw4A-4wqmA:
22.8		 5vw4A-4wqmA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 8 SER A 149
GLY A 210
CYH A 296
GLY A 297
 FAD  A 402 (-3.0A)
None
None
None
 0.55A 5vw5A-4wqmA:
22.6		 5vw5A-4wqmA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4wqm TOLUENE-4-MONOOXYGEN
ASE ELECTRON
TRANSFER COMPONENT
(Pseudomonas
mendocina) 		4 / 7 LEU A  74
PHE A  73
PHE A  13
LEU A  21
 FES  A 401 ( 4.1A)
None
None
None
 0.97A 6aycA-4wqmA:
undetectable		 6aycA-4wqmA:
12.69