SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 8 SER A  64
ALA A  68
THR A 290
ILE A  51
 None
 0.82A 1c9sI-4wr2A:
undetectable
1c9sJ-4wr2A:
undetectable		 1c9sI-4wr2A:
11.64
1c9sJ-4wr2A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 THR A  49
LEU A  45
LEU A  69
ARG A 104
LEU A 295
 None
 1.25A 1errA-4wr2A:
undetectable		 1errA-4wr2A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.22A 1f86B-4wr2A:
undetectable		 1f86B-4wr2A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 7 ALA A  68
THR A 290
ILE A  51
SER A  64
 None
 0.80A 1gtnA-4wr2A:
undetectable
1gtnK-4wr2A:
undetectable		 1gtnA-4wr2A:
11.64
1gtnK-4wr2A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 10 HIS A  59
GLY A  58
LEU A 102
LEU A 138
PRO A 139
 None
 1.28A 1mjqG-4wr2A:
undetectable
1mjqH-4wr2A:
undetectable		 1mjqG-4wr2A:
14.60
1mjqH-4wr2A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 ILE A 123
LEU A 121
VAL A 215
ALA A 220
 None
 0.95A 1mz9A-4wr2A:
undetectable		 1mz9A-4wr2A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 THR A 320
GLY A 308
ILE A 176
LEU A 167
VAL A 168
 None
 1.18A 1r30A-4wr2A:
undetectable		 1r30A-4wr2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 THR A 320
GLY A 308
ILE A 176
LEU A 167
VAL A 168
 None
 1.19A 1r30B-4wr2A:
undetectable		 1r30B-4wr2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.32A 2roxA-4wr2A:
undetectable		 2roxA-4wr2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 LEU A 195
GLY A 171
THR A 320
VAL A 307
ILE A 230
 None
CA  A 401 ( 4.1A)
None
None
None
 0.96A 3c6gA-4wr2A:
undetectable		 3c6gA-4wr2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 GLY A 344
GLN A 343
LEU A 285
CYH A 289
PHE A 300
 None
 1.28A 3cldB-4wr2A:
undetectable		 3cldB-4wr2A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 GLY A 344
GLN A 343
ARG A 250
CYH A 289
PHE A 300
 None
 1.49A 3gn8B-4wr2A:
undetectable		 3gn8B-4wr2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 LEU A 101
MET A 107
ILE A 349
ASP A 287
 None
None
None
CA  A 401 (-3.0A)
 1.47A 3hecA-4wr2A:
undetectable		 3hecA-4wr2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 5 ILE A  63
PHE A 269
ASP A 267
GLU A 264
 None
 1.11A 3kp6A-4wr2A:
undetectable
3kp6B-4wr2A:
undetectable		 3kp6A-4wr2A:
19.12
3kp6B-4wr2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 GLY A 344
GLN A 343
ARG A 250
LEU A 285
PHE A 300
 None
 1.45A 3mneA-4wr2A:
undetectable		 3mneA-4wr2A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 GLN A  86
GLY A  58
ASP A  61
MET A 196
ASN A 212
 None
None
CA  A 401 (-2.3A)
None
CA  A 401 ( 4.4A)
 1.31A 3t7sB-4wr2A:
undetectable		 3t7sB-4wr2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 GLN A  86
GLY A  58
ASP A  61
MET A 196
ASN A 212
 None
None
CA  A 401 (-2.3A)
None
CA  A 401 ( 4.4A)
 1.32A 3t7sD-4wr2A:
2.6		 3t7sD-4wr2A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 ASP A 287
PRO A  57
ILE A 213
MET A 196
ASP A  56
 CA  A 401 (-3.0A)
None
None
None
CA  A 401 (-3.1A)
 1.39A 3topA-4wr2A:
undetectable		 3topA-4wr2A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 10 GLY A 112
ALA A 150
ILE A 151
ILE A 180
ILE A 176
 None
 1.02A 4dt8B-4wr2A:
undetectable		 4dt8B-4wr2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 ALA A 199
GLY A 234
ILE A 213
ASN A 212
MET A 196
 1PE  A 402 ( 4.4A)
None
None
CA  A 401 ( 4.4A)
None
 1.24A 4obwA-4wr2A:
undetectable		 4obwA-4wr2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 ALA A 199
GLY A 234
ILE A 213
ASN A 212
MET A 196
 1PE  A 402 ( 4.4A)
None
None
CA  A 401 ( 4.4A)
None
 1.26A 4obwD-4wr2A:
undetectable		 4obwD-4wr2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 9 THR A 320
ALA A 220
ALA A 219
GLY A 198
GLY A 197
 None
 1.15A 4qwuK-4wr2A:
undetectable
4qwuL-4wr2A:
undetectable		 4qwuK-4wr2A:
20.77
4qwuL-4wr2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 9 THR A 320
ALA A 220
ALA A 219
GLY A 198
GLY A 197
 None
 1.11A 4qwuY-4wr2A:
undetectable
4qwuZ-4wr2A:
undetectable		 4qwuY-4wr2A:
20.77
4qwuZ-4wr2A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 THR A  49
LEU A  45
LEU A  69
ARG A 104
LEU A 295
 None
 1.33A 4xi3A-4wr2A:
undetectable		 4xi3A-4wr2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		5 / 12 VAL A 190
ILE A 228
ILE A 176
ASN A 175
VAL A 158
 None
 0.92A 5uvmB-4wr2A:
undetectable		 5uvmB-4wr2A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 GLN A  86
THR A  91
THR A 174
LEU A 121
 None
 1.50A 6f3mC-4wr2A:
8.6		 6f3mC-4wr2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.31A 6gnrA-4wr2A:
undetectable		 6gnrA-4wr2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA
(Shewanella
loihica) 		4 / 4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.32A 6gnrB-4wr2A:
undetectable		 6gnrB-4wr2A:
19.64