SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.68A 11gsB-4wr4A:
26.0		 11gsB-4wr4A:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 TYR A 110
GLY A 204
TYR A   6
GLY A  11
 None
 0.81A 11gsB-4wr4A:
26.0		 11gsB-4wr4A:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 LEU A  81
ALA A  75
PRO A  15
THR A  16
LEU A  99
 None
 1.05A 1cbsA-4wr4A:
undetectable		 1cbsA-4wr4A:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		3 / 3 GLN A  66
TYR A 103
ARG A 107
 GSH  A 301 (-3.2A)
None
None
 0.40A 1gtbA-4wr4A:
34.1		 1gtbA-4wr4A:
87.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 TYR A 110
GLY A 210
VAL A 160
TRP A 205
GLY A  11
 None
None
BYR  A 163 ( 4.8A)
None
None
 1.22A 1kiaB-4wr4A:
undetectable		 1kiaB-4wr4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 11 ILE A  71
ILE A  74
GLY A  11
LEU A   4
TYR A  27
 None
BYR  A  73 ( 4.3A)
None
BYR  A  57 ( 4.4A)
None
 1.09A 2azyA-4wr4A:
undetectable		 2azyA-4wr4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 LEU A  81
ALA A  75
PRO A  15
THR A  16
LEU A  99
 None
 1.07A 2fr3A-4wr4A:
undetectable		 2fr3A-4wr4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 5 TYR A 103
ALA A 109
ALA A 157
MET A 128
 None
 1.09A 3d91A-4wr4A:
undetectable		 3d91A-4wr4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.78A 3n9jB-4wr4A:
25.8		 3n9jB-4wr4A:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 PHE A 121
GLN A 203
ALA A 109
ASP A 165
MET A 164
 None
 1.24A 4j7xA-4wr4A:
undetectable		 4j7xA-4wr4A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 SER A 106
LEU A 125
MET A 128
ARG A 102
LEU A 158
 None
 1.08A 4x1fA-4wr4A:
undetectable		 4x1fA-4wr4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 SER A 106
LEU A 125
MET A 128
ARG A 102
LEU A 158
 None
 1.05A 4x1gA-4wr4A:
undetectable		 4x1gA-4wr4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 9 LEU A   4
GLY A   5
ILE A  74
VAL A  13
THR A  16
 BYR  A  57 ( 4.4A)
BYR  A  32 ( 4.5A)
BYR  A  73 ( 4.3A)
None
None
 1.16A 4x3mA-4wr4A:
undetectable		 4x3mA-4wr4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 9 LEU A   4
GLY A   5
ILE A  74
VAL A  13
THR A  16
 BYR  A  57 ( 4.4A)
BYR  A  32 ( 4.5A)
BYR  A  73 ( 4.3A)
None
None
 1.15A 4x3mB-4wr4A:
undetectable		 4x3mB-4wr4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 7 VAL A 105
SER A 106
ALA A 109
GLY A 210
 None
 0.58A 5fpdA-4wr4A:
undetectable		 5fpdA-4wr4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		4 / 8 THR A  16
PRO A  15
ILE A  70
PRO A  55
 None
None
BYR  A  57 ( 3.8A)
GSH  A 301 (-4.5A)
 1.02A 6a4iA-4wr4A:
2.1		 6a4iA-4wr4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 12 LEU A 169
ALA A 157
LEU A 142
LEU A 129
LEU A 175
 None
None
BYR  A 141 ( 4.3A)
None
None
 0.97A 6f6iA-4wr4A:
undetectable
6f6iB-4wr4A:
undetectable		 6f6iA-4wr4A:
14.96
6f6iB-4wr4A:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME
(Schistosoma
japonicum) 		5 / 5 GLY A  11
LEU A  12
SER A 106
TYR A 110
GLN A 203
 None
GSH  A 301 (-4.1A)
None
None
None
 0.30A 6ji6A-4wr4A:
34.8		 6ji6A-4wr4A:
87.30