SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wrl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 4 ALA A 226
VAL A 235
ALA A 280
HIS A 287
 None
 1.26A 1q23F-4wrlA:
undetectable		 1q23F-4wrlA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A  58
GLN A  77
TRP A 159
 None
FUC  A 402 (-4.0A)
None
 1.08A 2vqyA-4wrlA:
undetectable		 2vqyA-4wrlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 7 VAL A 101
LEU A  99
TYR A  82
LEU A 111
 None
 0.97A 3qeoB-4wrlA:
undetectable		 3qeoB-4wrlA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 GLY A 201
PRO A 202
ALA A 280
 None
 0.53A 4qn9B-4wrlA:
undetectable		 4qn9B-4wrlA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 148
SER A 139
PHE A 156
GLU A 135
 None
 1.07A 5b8iA-4wrlA:
undetectable		 5b8iA-4wrlA:
19.34