SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 PHE A 156
TYR A 100
PRO A 158
 None
 1.00A 1mcnA-4wrmA:
7.4
1mcnB-4wrmA:
9.1
1mcnP-4wrmA:
undetectable		 1mcnA-4wrmA:
20.66
1mcnB-4wrmA:
20.66
1mcnP-4wrmA:
0.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 4 ALA A 226
VAL A 235
ALA A 280
HIS A 287
 None
 1.25A 1q23F-4wrmA:
undetectable		 1q23F-4wrmA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 TRP A  58
GLN A  77
TRP A 159
 None
 0.94A 2vqyA-4wrmA:
undetectable		 2vqyA-4wrmA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 9 ILE A  23
LEU A  40
PRO A 158
SER A 157
GLY A  80
 None
 1.39A 3w1wB-4wrmA:
0.0		 3w1wB-4wrmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A 486
HIS A 488
SER A 495
 None
 0.84A 4mjwA-4wrmA:
undetectable
4mjwB-4wrmA:
undetectable		 4mjwA-4wrmA:
23.21
4mjwB-4wrmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 495
ARG A 486
HIS A 488
 None
 0.83A 4mjwA-4wrmA:
undetectable
4mjwB-4wrmA:
undetectable		 4mjwA-4wrmA:
23.21
4mjwB-4wrmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		3 / 3 GLY A 201
PRO A 202
ALA A 280
 None
 0.53A 4qn9B-4wrmA:
undetectable		 4qn9B-4wrmA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 148
SER A 139
PHE A 156
GLU A 135
 None
 1.08A 5b8iA-4wrmA:
undetectable		 5b8iA-4wrmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		5 / 9 PRO A 455
GLY A 423
SER A 470
VAL A 457
LEU A 458
 None
 1.35A 5o96E-4wrmA:
undetectable
5o96F-4wrmA:
undetectable		 5o96E-4wrmA:
19.26
5o96F-4wrmA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens) 		4 / 5 PRO A 427
GLY A 423
TYR A 424
VAL A 491
 None
 1.37A 5x80C-4wrmA:
undetectable
5x80D-4wrmA:
undetectable		 5x80C-4wrmA:
17.89
5x80D-4wrmA:
17.89