SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A  32
VAL A  74
ILE A  84
ASN A 291
 None
 0.96A 1e06A-4wrnA:
undetectable		 1e06A-4wrnA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLU A 155
LEU A 159
MET A 248
LEU A 139
 None
 1.08A 1linA-4wrnA:
undetectable		 1linA-4wrnA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 GLU A 135
TRP A 254
LYS A 297
 MAL  A 801 (-2.8A)
MAL  A 801 ( 3.6A)
None
 1.05A 1qu2A-4wrnA:
undetectable		 1qu2A-4wrnA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASP A 595
PHE A 556
ARG A 598
 None
 0.83A 2a3aA-4wrnA:
undetectable		 2a3aA-4wrnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ASP A 221
THR A 217
LYS A 224
ASP A 382
 None
 1.27A 2j2pE-4wrnA:
undetectable
2j2pF-4wrnA:
undetectable		 2j2pE-4wrnA:
15.21
2j2pF-4wrnA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A 699
LEU A 562
MET A 531
THR A 604
 None
 1.17A 2oaxD-4wrnA:
undetectable		 2oaxD-4wrnA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 132
LEU A 286
ILE A  83
VAL A  47
LEU A  44
 None
 1.02A 3a51C-4wrnA:
undetectable		 3a51C-4wrnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PHE A 282
ALA A 186
LEU A 271
PRO A 183
 None
 0.98A 3bgdA-4wrnA:
undetectable		 3bgdA-4wrnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 134
GLY A 324
PRO A 253
LYS A 329
 None
 0.78A 3bjwC-4wrnA:
undetectable		 3bjwC-4wrnA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 ILE A 623
ASN A 700
VAL A 587
GLY A 588
 None
 0.84A 3em0B-4wrnA:
undetectable		 3em0B-4wrnA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 150
LEU A 171
ALA A 247
PRO A 149
 None
 1.24A 3gv1A-4wrnA:
undetectable
3gv1C-4wrnA:
undetectable		 3gv1A-4wrnA:
10.07
3gv1C-4wrnA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 171
ALA A 247
PRO A 149
PRO A 150
 None
 1.24A 3gv1A-4wrnA:
undetectable
3gv1B-4wrnA:
undetectable		 3gv1A-4wrnA:
10.07
3gv1B-4wrnA:
10.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		11 / 12 ASP A  38
LYS A  39
GLU A  68
GLU A  69
ALA A  87
ASP A  89
ARG A  90
GLU A 135
PRO A 178
TRP A 254
TYR A 365
 MAL  A 801 (-3.0A)
MAL  A 801 (-3.0A)
None
None
MAL  A 801 (-2.8A)
MAL  A 801 (-2.8A)
None
MAL  A 801 (-2.8A)
MAL  A 801 (-3.2A)
MAL  A 801 ( 3.6A)
None
 0.73A 3jyrA-4wrnA:
59.5		 3jyrA-4wrnA:
48.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		11 / 12 ASP A  38
LYS A  39
LYS A  66
GLU A  68
GLU A  69
ALA A  87
ASP A  89
ARG A  90
GLU A 135
PRO A 178
TRP A 254
 MAL  A 801 (-3.0A)
MAL  A 801 (-3.0A)
None
None
None
MAL  A 801 (-2.8A)
MAL  A 801 (-2.8A)
None
MAL  A 801 (-2.8A)
MAL  A 801 (-3.2A)
MAL  A 801 ( 3.6A)
 0.56A 3jyrA-4wrnA:
59.5		 3jyrA-4wrnA:
48.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		7 / 7 ASN A  36
TRP A  86
GLU A 177
TYR A 179
MET A 354
TRP A 364
ARG A 368
 None
MAL  A 801 (-4.1A)
MAL  A 801 (-3.0A)
MAL  A 801 (-2.9A)
MAL  A 801 ( 3.8A)
MAL  A 801 (-3.0A)
None
 0.75A 3jyrA-4wrnA:
59.5		 3jyrA-4wrnA:
48.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.21A 3lxiA-4wrnA:
undetectable		 3lxiA-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.22A 3lxiB-4wrnA:
undetectable		 3lxiB-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 TYR A 586
VAL A 668
MET A 652
ARG A 559
 None
 1.27A 3ms9B-4wrnA:
undetectable		 3ms9B-4wrnA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR A 569
SER A 567
ARG A 495
 None
 0.81A 3phnA-4wrnA:
undetectable		 3phnA-4wrnA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ILE A 156
LEU A 222
LYS A 280
ILE A 250
GLY A 215
 None
 1.09A 3sj4X-4wrnA:
undetectable		 3sj4X-4wrnA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 180
GLY A 324
LEU A 323
GLU A 135
ALA A 255
 None
None
None
MAL  A 801 (-2.8A)
None
 0.81A 3tbgB-4wrnA:
undetectable		 3tbgB-4wrnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE A 180
GLY A 324
LEU A 323
GLU A 135
ALA A 255
 None
None
None
MAL  A 801 (-2.8A)
None
 0.79A 3tbgD-4wrnA:
undetectable		 3tbgD-4wrnA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.24A 4c9kA-4wrnA:
undetectable		 4c9kA-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.25A 4c9nB-4wrnA:
undetectable		 4c9nB-4wrnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.24A 4c9pA-4wrnA:
undetectable		 4c9pA-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 THR A 589
LEU A 601
LEU A 602
GLY A 641
VAL A 637
 None
 1.25A 4c9pB-4wrnA:
undetectable		 4c9pB-4wrnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ARG A 559
LEU A 601
MET A 590
ASP A 592
 None
 1.10A 4cevA-4wrnA:
undetectable
4cevB-4wrnA:
undetectable		 4cevA-4wrnA:
18.52
4cevB-4wrnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 MET A 590
ASP A 592
ARG A 559
LEU A 601
 None
 1.07A 4cevA-4wrnA:
undetectable
4cevC-4wrnA:
undetectable		 4cevA-4wrnA:
18.52
4cevC-4wrnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ARG A 559
LEU A 601
MET A 590
ASP A 592
 None
 1.09A 4cevD-4wrnA:
undetectable
4cevE-4wrnA:
undetectable		 4cevD-4wrnA:
18.52
4cevE-4wrnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 ARG A 559
LEU A 601
MET A 590
ASP A 592
 None
 1.09A 4cevE-4wrnA:
undetectable
4cevF-4wrnA:
undetectable		 4cevE-4wrnA:
18.52
4cevF-4wrnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ILE A 156
LEU A 163
LEU A 146
ALA A 247
LEU A 139
 None
 1.09A 4p65E-4wrnA:
undetectable
4p65F-4wrnA:
undetectable
4p65J-4wrnA:
undetectable
4p65L-4wrnA:
undetectable		 4p65E-4wrnA:
3.06
4p65F-4wrnA:
3.70
4p65J-4wrnA:
3.70
4p65L-4wrnA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 GLY A 588
LEU A 579
PHE A 653
ILE A 704
 None
 0.81A 4xv2A-4wrnA:
undetectable		 4xv2A-4wrnA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 207
LEU A 385
ALA A 370
ILE A 250
ILE A 185
 None
 1.12A 5hbsA-4wrnA:
undetectable		 5hbsA-4wrnA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 139
LEU A 146
ASN A 142
ALA A 170
ILE A 156
 None
 1.08A 5itzB-4wrnA:
undetectable		 5itzB-4wrnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 163
LEU A 146
ASN A 148
ILE A 156
LYS A 151
 None
 1.11A 5itzB-4wrnA:
undetectable		 5itzB-4wrnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 328
ILE A 353
THR A 117
MET A 345
 None
 1.31A 5ljeA-4wrnA:
undetectable		 5ljeA-4wrnA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 367
GLY A 215
LEU A 219
THR A 217
 None
 1.03A 5sxqB-4wrnA:
undetectable		 5sxqB-4wrnA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLU A 639
ARG A 647
GLY A 588
GLY A 641
SER A 643
 None
 1.07A 5vooB-4wrnA:
undetectable		 5vooB-4wrnA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLU A 639
ARG A 647
GLY A 588
GLY A 641
SER A 643
 None
 1.12A 5vooC-4wrnA:
undetectable		 5vooC-4wrnA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 366
ALA A 362
GLY A 190
ALA A 212
PHE A 193
VAL A 205
 None
 1.42A 5w4zA-4wrnA:
undetectable		 5w4zA-4wrnA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		6 / 12 ALA A 366
ALA A 362
GLY A 190
ALA A 212
PHE A 193
VAL A 205
 None
 1.45A 5w4zB-4wrnA:
undetectable		 5w4zB-4wrnA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 179
ASN A 251
LEU A 137
 MAL  A 801 (-2.9A)
None
None
 0.82A 6b58A-4wrnA:
undetectable		 6b58A-4wrnA:
20.59