SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  52
VAL A  49
TRP A 145
 None
 0.86A 1kqeA-4wrwA:
undetectable
1kqeE-4wrwA:
undetectable		 1kqeA-4wrwA:
8.64
1kqeE-4wrwA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  52
VAL A  49
TRP A 145
 None
 0.85A 1kqeB-4wrwA:
undetectable
1kqeD-4wrwA:
undetectable		 1kqeB-4wrwA:
8.64
1kqeD-4wrwA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 145
ALA A  52
VAL A  49
 None
 0.86A 1kqeB-4wrwA:
undetectable
1kqeD-4wrwA:
undetectable		 1kqeB-4wrwA:
8.64
1kqeD-4wrwA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 145
ALA A  52
VAL A  49
 None
 0.84A 1kqeA-4wrwA:
undetectable
1kqeE-4wrwA:
undetectable		 1kqeA-4wrwA:
8.64
1kqeE-4wrwA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A  52
VAL A  49
TRP A 145
 None
 0.90A 1micA-4wrwA:
undetectable
1micB-4wrwA:
undetectable		 1micA-4wrwA:
6.13
1micB-4wrwA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A   9
ALA A  26
GLY A  29
ARG A  33
 None
 0.94A 2wq5A-4wrwA:
undetectable		 2wq5A-4wrwA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 110
GLU A 100
TYR A 101
 None
 0.76A 2zmbA-4wrwA:
undetectable		 2zmbA-4wrwA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 210
VAL A 123
ILE A  97
LEU A 115
ILE A  64
 None
 1.16A 3jw3A-4wrwA:
undetectable		 3jw3A-4wrwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 210
VAL A 123
ILE A  97
LEU A 115
ILE A  64
 None
 1.13A 3jw3B-4wrwA:
undetectable		 3jw3B-4wrwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 194
ILE A  97
GLY A  66
ASP A 171
LEU A 179
 None
None
GOL  A 307 (-3.5A)
None
None
 1.12A 3v8vA-4wrwA:
undetectable		 3v8vA-4wrwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 127
GLY A  66
ILE A  97
PHE A 207
 GOL  A 307 (-2.8A)
GOL  A 307 (-3.5A)
None
None
 0.89A 4fglD-4wrwA:
undetectable		 4fglD-4wrwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 226
ARG A 225
ALA A 103
ARG A 121
GLY A 122
 None
None
GOL  A 304 ( 3.7A)
None
None
 1.19A 4l9qA-4wrwA:
undetectable		 4l9qA-4wrwA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  63
ILE A 153
MET A 178
GLY A  66
LEU A 126
 None
None
None
GOL  A 307 (-3.5A)
None
 0.91A 4lmnA-4wrwA:
undetectable		 4lmnA-4wrwA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		7 / 8 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
SER A  93
ASN A 127
 GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
CL  A 301 ( 3.1A)
GOL  A 307 (-2.8A)
 0.23A 4wryA-4wrwA:
39.9		 4wryA-4wrwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		7 / 8 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
SER A  93
ASN A 127
 GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
CL  A 301 ( 3.1A)
GOL  A 307 (-2.8A)
 0.31A 4wrzA-4wrwA:
38.8		 4wrzA-4wrwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		6 / 7 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
ASN A 127
 GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
GOL  A 307 (-2.8A)
 0.70A 4ws0A-4wrwA:
38.1		 4ws0A-4wrwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		7 / 8 GLY A  66
GLN A  67
TYR A  70
SER A  80
PHE A  81
SER A  93
ASN A 127
 GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
None
GOL  A 307 (-3.5A)
CL  A 301 ( 3.1A)
GOL  A 307 (-2.8A)
 0.76A 4ws1A-4wrwA:
38.3		 4ws1A-4wrwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 206
ARG A 209
GLU A 100
 None
 0.66A 5j6hA-4wrwA:
undetectable		 5j6hA-4wrwA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  79
ALA A  52
PHE A  55
ILE A  64
LEU A 179
 None
None
GOL  A 305 ( 4.8A)
None
None
 1.22A 5ljbA-4wrwA:
undetectable		 5ljbA-4wrwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 4wrw URACIL-DNA
GLYCOSYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  21
LEU A  63
PHE A  53
LEU A 124
LEU A 130
 None
 1.21A 6ew0G-4wrwA:
undetectable		 6ew0G-4wrwA:
17.65