SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 ILE C 310
CYH C 311
ALA C 313
ALA C 314
VAL C 518
 None
None
None
None
PO4  C 801 ( 4.1A)
 0.99A 1fbyB-4wsbC:
undetectable		 1fbyB-4wsbC:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 SER C 226
ILE C 147
ILE C 220
LEU C 218
HIS C 233
 None
 1.12A 1kyvA-4wsbC:
undetectable
1kyvE-4wsbC:
undetectable		 1kyvA-4wsbC:
11.97
1kyvE-4wsbC:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 ILE C 220
LEU C 218
HIS C 233
SER C 226
ILE C 147
 None
 0.93A 1kyvB-4wsbC:
undetectable
1kyvC-4wsbC:
undetectable		 1kyvB-4wsbC:
11.97
1kyvC-4wsbC:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 ILE C 220
LEU C 218
HIS C 233
SER C 226
ILE C 147
 None
 0.93A 1kyvC-4wsbC:
undetectable
1kyvD-4wsbC:
undetectable		 1kyvC-4wsbC:
11.97
1kyvD-4wsbC:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 ILE C 220
LEU C 218
HIS C 233
SER C 226
ILE C 147
 None
 0.94A 1kyvD-4wsbC:
undetectable
1kyvE-4wsbC:
undetectable		 1kyvD-4wsbC:
11.97
1kyvE-4wsbC:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.80A 1v54A-4wsbC:
2.1
1v54J-4wsbC:
undetectable		 1v54A-4wsbC:
22.62
1v54J-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.84A 2dyrA-4wsbC:
undetectable
2dyrJ-4wsbC:
undetectable		 2dyrA-4wsbC:
22.62
2dyrJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.78A 2dysA-4wsbC:
undetectable
2dysJ-4wsbC:
undetectable		 2dysA-4wsbC:
22.62
2dysJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.74A 2dysN-4wsbC:
2.0
2dysW-4wsbC:
undetectable		 2dysN-4wsbC:
22.62
2dysW-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.78A 2eijA-4wsbC:
undetectable
2eijJ-4wsbC:
undetectable		 2eijA-4wsbC:
22.62
2eijJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.75A 2eilA-4wsbC:
undetectable
2eilJ-4wsbC:
undetectable		 2eilA-4wsbC:
22.62
2eilJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 8 THR C 227
SER C 225
ALA C 250
PRO C 246
 None
 1.00A 2v32A-4wsbC:
undetectable
2v32B-4wsbC:
undetectable		 2v32A-4wsbC:
15.36
2v32B-4wsbC:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 8 THR C 227
SER C 225
ALA C 250
PRO C 246
 None
 0.95A 2v41G-4wsbC:
undetectable
2v41H-4wsbC:
undetectable		 2v41G-4wsbC:
15.36
2v41H-4wsbC:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.90A 3abmA-4wsbC:
undetectable
3abmJ-4wsbC:
undetectable		 3abmA-4wsbC:
22.62
3abmJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.83A 3asnA-4wsbC:
undetectable
3asnJ-4wsbC:
undetectable		 3asnA-4wsbC:
22.62
3asnJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.79A 3asoA-4wsbC:
2.1
3asoJ-4wsbC:
undetectable		 3asoA-4wsbC:
22.62
3asoJ-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 GLY C 367
PHE C 330
SER C 324
ASP C 393
LEU C 397
 None
 0.98A 3iv6D-4wsbC:
undetectable		 3iv6D-4wsbC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 7 ARG C 692
GLN C 581
SER C 622
ILE C 584
 None
 1.07A 3ln1C-4wsbC:
undetectable		 3ln1C-4wsbC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 11 LEU C 280
SER C 279
ILE C 310
ALA C 262
ALA C 307
 None
 1.13A 3mdtB-4wsbC:
undetectable		 3mdtB-4wsbC:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 7 LYS C 134
ASN C 530
VAL C 539
GLU C 538
 None
 1.23A 4mv7A-4wsbC:
undetectable		 4mv7A-4wsbC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 ILE C 163
LYS C 189
LEU C 211
GLU C 210
 None
 0.82A 4w5nA-4wsbC:
undetectable		 4w5nA-4wsbC:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 ARG C 650
ILE C 649
GLN C 614
ILE C 696
 None
 1.10A 4w5qA-4wsbC:
undetectable		 4w5qA-4wsbC:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 ARG C 650
ILE C 649
GLN C 614
ILE C 696
 None
 1.19A 4w5tA-4wsbC:
undetectable		 4w5tA-4wsbC:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 9 ARG C 299
LEU C 298
LEU C 280
ILE C 266
SER C 282
 None
 1.36A 4z69A-4wsbC:
undetectable		 4z69A-4wsbC:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 12 SER C 653
SER C 688
PHE C 600
PHE C 595
GLY C 727
 None
 1.44A 4zjlA-4wsbC:
undetectable		 4zjlA-4wsbC:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		5 / 10 VAL C 672
GLY C 673
TRP C 557
LEU C 680
TYR C 658
 None
 1.16A 6bsgA-4wsbC:
undetectable		 6bsgA-4wsbC:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 6 ARG C 650
ILE C 649
GLN C 614
ILE C 696
 None
 1.19A 6cbdA-4wsbC:
undetectable		 6cbdA-4wsbC:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 5 ILE C 163
LEU C 207
ARG C 157
LEU C 154
 None
 0.68A 6nmpN-4wsbC:
undetectable
6nmpW-4wsbC:
undetectable		 6nmpN-4wsbC:
22.62
6nmpW-4wsbC:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wsb POLYMERASE PB2
(Influenza
A
virus) 		4 / 5 LEU C 207
ARG C 157
THR C 155
LEU C 154
 None
 0.67A 6nmpN-4wsbC:
undetectable
6nmpW-4wsbC:
undetectable		 6nmpN-4wsbC:
22.62
6nmpW-4wsbC:
5.53