SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wse'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 SER A 246
GLY A 247
ARG A 390
 None
 0.56A 1t9wA-4wseA:
2.7		 1t9wA-4wseA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		4 / 6 GLY A 328
THR A 327
LEU A 323
GLU A 345
 None
 0.96A 3ps9A-4wseA:
undetectable		 3ps9A-4wseA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 TYR A 344
ASP A 394
ALA A 391
TYR A 403
 None
 1.07A 3rodA-4wseA:
undetectable		 3rodA-4wseA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 LEU A 109
CYH A 110
ILE A  52
ILE A 144
ASP A  94
 None
 1.19A 3vw1D-4wseA:
undetectable		 3vw1D-4wseA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TYR A 320
PHE A 286
ARG A 342
 None
 1.15A 4g19D-4wseA:
undetectable		 4g19D-4wseA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		4 / 8 ILE A 341
LYS A 373
ILE A 245
GLY A 346
 None
 0.89A 4hdlA-4wseA:
undetectable		 4hdlA-4wseA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TYR A 254
ARG A 435
SER A 376
 None
 1.03A 4khpI-4wseA:
undetectable
4khpJ-4wseA:
undetectable		 4khpI-4wseA:
12.57
4khpJ-4wseA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TYR A 254
ARG A 435
SER A 376
 None
 1.17A 4lf7I-4wseA:
undetectable
4lf7J-4wseA:
undetectable		 4lf7I-4wseA:
13.26
4lf7J-4wseA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		3 / 3 TYR A 254
ARG A 435
SER A 376
 None
 1.17A 4lf8I-4wseA:
undetectable
4lf8J-4wseA:
undetectable		 4lf8I-4wseA:
13.26
4lf8J-4wseA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 LYS A  57
ASP A 161
ILE A 160
TYR A 165
 None
 1.19A 5a06B-4wseA:
undetectable		 5a06B-4wseA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ASP A 105
THR A 101
TYR A 146
PRO A 100
 None
 1.31A 5b6iA-4wseA:
undetectable		 5b6iA-4wseA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		4 / 7 ALA A  72
THR A  71
TYR A  87
GLU A  96
 None
 1.20A 5ecnA-4wseA:
undetectable		 5ecnA-4wseA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 144
ILE A 134
LEU A 109
ASP A  94
LEU A 140
 None
 1.22A 5km9B-4wseA:
undetectable		 5km9B-4wseA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.92A 5n0sA-4wseA:
undetectable		 5n0sA-4wseA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.91A 5n0tA-4wseA:
undetectable		 5n0tA-4wseA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.91A 5n0tB-4wseA:
undetectable		 5n0tB-4wseA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 380
VAL A 375
ALA A 282
 None
 1.21A 5n0wA-4wseA:
undetectable		 5n0wA-4wseA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.88A 5n0wB-4wseA:
undetectable		 5n0wB-4wseA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.91A 5n0xA-4wseA:
undetectable		 5n0xA-4wseA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 248
GLY A 247
VAL A 375
ILE A 281
ALA A 282
 None
 0.89A 5n4iA-4wseA:
undetectable		 5n4iA-4wseA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4wse PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT
(Acanthamoeba
polyphaga
mimivirus) 		5 / 12 ILE A 407
ILE A 386
LEU A 381
LEU A 172
LEU A 176
 None
 0.94A 5tiwA-4wseA:
undetectable		 5tiwA-4wseA:
18.46