SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 147
LEU A 152
THR A 151
VAL A 190
 None
 1.01A 1ekjF-4wshA:
1.5
1ekjG-4wshA:
undetectable		 1ekjF-4wshA:
20.89
1ekjG-4wshA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 201
GLY A 196
GLY A 123
ASP A 127
ARG A 130
 None
 1.22A 1mxdA-4wshA:
5.6		 1mxdA-4wshA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 6 THR A 250
ASP A 271
THR A 273
ASP A 294
 None
 1.09A 2okcB-4wshA:
undetectable		 2okcB-4wshA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 5 VAL A  23
ILE A  74
PHE A 145
PHE A 208
 None
 0.74A 3owxB-4wshA:
undetectable		 3owxB-4wshA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 209
GLY A 269
SER A 148
THR A 151
 None
 0.68A 4ac9C-4wshA:
2.8		 4ac9C-4wshA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  13
LEU A  10
LEU A   4
ILE A 247
GLN A 206
 None
 1.09A 4f4dA-4wshA:
undetectable		 4f4dA-4wshA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 243
ASP A   7
ASP A  71
 SO4  A 405 (-4.3A)
None
None
 0.83A 4kicB-4wshA:
undetectable		 4kicB-4wshA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 262
ARG A 286
GLN A 221
 None
 0.94A 4rtbA-4wshA:
7.4		 4rtbA-4wshA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 252
TRP A 211
TYR A 155
ASP A 209
 None
 1.26A 5vlmG-4wshA:
undetectable		 5vlmG-4wshA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 266
PHE A 145
SER A 210
MET A  26
 None
None
SO4  A 407 ( 4.7A)
SO4  A 407 ( 4.6A)
 1.01A 5y2tB-4wshA:
undetectable		 5y2tB-4wshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 247
GLN A 290
GLN A 206
ALA A 202
ILE A  74
 None
 1.36A 5zovA-4wshA:
0.0		 5zovA-4wshA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 247
GLN A 290
GLN A 206
ALA A 202
ILE A  74
 None
 1.43A 5zovB-4wshA:
undetectable		 5zovB-4wshA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4wsh UROPORPHYRINOGEN
DECARBOXYLASE
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 206
TRP A  24
VAL A 323
 None
 1.07A 6auuA-4wshA:
undetectable		 6auuA-4wshA:
19.24