SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		4 / 5 THR A 515
PHE A 536
GLU A 550
GLY A 549
 None
 1.25A 1icrA-4wsiA:
undetectable
1icrB-4wsiA:
undetectable		 1icrA-4wsiA:
21.14
1icrB-4wsiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		4 / 5 GLU A 550
GLY A 549
THR A 515
PHE A 536
 None
 1.28A 1icrA-4wsiA:
undetectable
1icrB-4wsiA:
undetectable		 1icrA-4wsiA:
21.14
1icrB-4wsiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		4 / 5 THR A 515
PHE A 536
GLU A 550
GLY A 549
 None
 1.20A 1icvC-4wsiA:
undetectable
1icvD-4wsiA:
undetectable		 1icvC-4wsiA:
21.14
1icvD-4wsiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		4 / 5 GLU A 550
GLY A 549
THR A 515
PHE A 536
 None
 1.14A 1icvC-4wsiA:
undetectable
1icvD-4wsiA:
undetectable		 1icvC-4wsiA:
21.14
1icvD-4wsiA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		4 / 6 PHE A 536
PHE A 545
THR A 515
VAL A 531
 None
 1.33A 3lb3B-4wsiA:
undetectable		 3lb3B-4wsiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		3 / 3 LEU A 574
ILE A 572
ARG A 506
 None
 0.70A 4mk4B-4wsiA:
4.0		 4mk4B-4wsiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		5 / 9 VAL A 563
LEU A 585
SER A 576
LEU A 484
ILE A 594
 None
 1.25A 4ubsA-4wsiA:
undetectable		 4ubsA-4wsiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		5 / 9 ARG A 498
LEU A 499
LEU A 484
ILE A 595
ALA A 651
 None
 1.47A 4z69A-4wsiA:
undetectable		 4z69A-4wsiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4wsi MAGUK P55 SUBFAMILY
MEMBER 5
(Homo
sapiens) 		4 / 8 ILE A 485
LEU A 577
ILE A 594
LEU A 585
 None
 0.71A 4zvcA-4wsiA:
undetectable
4zvcB-4wsiA:
undetectable		 4zvcA-4wsiA:
17.31
4zvcB-4wsiA:
17.31