SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 GLY A  35
HIS A  42
HIS A  45
GLY A 136
ASP A 138
 NAD  A 301 (-3.2A)
PO4  A 302 ( 4.2A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 0.80A 1jzsA-4wsoA:
undetectable		 1jzsA-4wsoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 GLY A  35
HIS A  45
GLY A 136
ASP A 138
GLN A 139
 NAD  A 301 (-3.2A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.7A)
 1.04A 1jzsA-4wsoA:
undetectable		 1jzsA-4wsoA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 HIS A 157
ALA A 156
PHE A 155
GLY A 195
 None
 1.17A 1mj2B-4wsoA:
undetectable		 1mj2B-4wsoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 HIS A 157
ALA A 156
PHE A 155
GLY A 195
 None
 1.23A 1mj2D-4wsoA:
undetectable		 1mj2D-4wsoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 HIS A 157
ALA A 156
PHE A 155
GLY A 195
 None
 1.19A 1mjoB-4wsoA:
undetectable		 1mjoB-4wsoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 HIS A 157
ALA A 156
PHE A 155
GLY A 195
 None
 1.15A 1mjoA-4wsoA:
undetectable		 1mjoA-4wsoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 4 HIS A 157
ALA A 156
PHE A 155
GLY A 195
 None
 1.19A 1mjoD-4wsoA:
undetectable		 1mjoD-4wsoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 HIS A  42
GLY A  44
HIS A  45
GLY A 136
ASP A 138
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 0.48A 1pg2A-4wsoA:
5.3		 1pg2A-4wsoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 HIS A  42
GLY A  44
HIS A  45
GLY A 136
ASP A 138
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 0.92A 1qu2A-4wsoA:
3.9		 1qu2A-4wsoA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 5 GLU A 105
PRO A  65
ILE A 106
GLY A  67
 NAD  A 301 ( 4.3A)
None
None
None
 1.18A 2qeuA-4wsoA:
undetectable
2qeuC-4wsoA:
undetectable		 2qeuA-4wsoA:
20.87
2qeuC-4wsoA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 HIS A  42
GLY A  44
HIS A  45
GLY A 136
ASP A 138
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 0.59A 2x1lA-4wsoA:
6.2		 2x1lA-4wsoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		6 / 12 HIS A  42
GLY A  44
HIS A  45
GLY A 136
ASP A 138
LEU A 205
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
None
 0.79A 2x1lB-4wsoA:
4.2		 2x1lB-4wsoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 11 HIS A  42
GLY A  44
HIS A  45
GLY A 136
ASP A 138
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 0.57A 2x1lC-4wsoA:
4.7		 2x1lC-4wsoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 ASP A  54
ARG A  50
ALA A  53
 None
 0.72A 3mbgC-4wsoA:
undetectable		 3mbgC-4wsoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 8 SER A 100
ALA A  88
LEU A  92
THR A  85
 None
 0.99A 4iklA-4wsoA:
undetectable
4iklB-4wsoA:
undetectable		 4iklA-4wsoA:
20.39
4iklB-4wsoA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 HIS A  42
GLY A  44
LEU A  48
GLY A 136
ASP A 138
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
NAD  A 301 (-4.2A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 1.10A 5hg0A-4wsoA:
7.2		 5hg0A-4wsoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		6 / 12 HIS A  42
GLY A  44
HIS A  45
LEU A  48
GLY A 136
ASP A 138
 PO4  A 302 ( 4.2A)
NAD  A 301 ( 3.8A)
PO4  A 302 ( 4.0A)
NAD  A 301 (-4.2A)
NAD  A 301 (-3.1A)
NAD  A 301 (-2.9A)
 1.02A 5hg0B-4wsoA:
7.2		 5hg0B-4wsoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 10 GLY A  32
ALA A 102
VAL A  62
MET A  64
ILE A  31
 None
 0.86A 5i3cB-4wsoA:
undetectable		 5i3cB-4wsoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 135
THR A 202
ALA A 156
ILE A 179
PHE A 168
 NAD  A 301 (-4.1A)
None
None
None
None
 1.38A 5iwuA-4wsoA:
undetectable		 5iwuA-4wsoA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4wso PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Burkholderia
thailandensis) 		4 / 7 GLY A  36
THR A  37
PHE A  38
HIS A  45
 NAD  A 301 (-3.2A)
NAD  A 301 (-3.6A)
NAD  A 301 (-4.7A)
PO4  A 302 ( 4.0A)
 0.45A 6jnhA-4wsoA:
13.1		 6jnhA-4wsoA:
22.71