SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2
(Arabidopsis
thaliana) 		5 / 11 PHE A 365
PHE A 295
LEU A 347
VAL A 353
VAL A 345
 None
 1.43A 1q23J-4wt5A:
undetectable		 1q23J-4wt5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2
(Arabidopsis
thaliana) 		5 / 9 ALA A 385
VAL A 361
GLY A 360
LEU A 400
LEU A 424
 None
 0.99A 2z0yA-4wt5A:
undetectable		 2z0yA-4wt5A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2
(Arabidopsis
thaliana) 		5 / 9 ALA A 385
VAL A 361
GLY A 359
LEU A 400
LEU A 424
 None
 0.92A 2z0yB-4wt5A:
undetectable		 2z0yB-4wt5A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2
(Arabidopsis
thaliana) 		5 / 12 LEU A 400
LEU A 415
PHE A 365
GLY A 406
ALA A 403
 None
 1.07A 3n8xB-4wt5A:
undetectable		 3n8xB-4wt5A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2
(Arabidopsis
thaliana) 		3 / 3 VAL A 298
SER A 349
TRP A 350
 None
 0.71A 5jwaA-4wt5A:
undetectable		 5jwaA-4wt5A:
15.00