SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wt7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		3 / 3 TRP A 240
ALA A 238
VAL A 174
 None
 0.98A 1av2C-4wt7A:
undetectable
1av2D-4wt7A:
undetectable		 1av2C-4wt7A:
5.50
1av2D-4wt7A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 GLY A 249
ALA A 255
THR A 264
SER A 282
 None
 0.92A 1c9sT-4wt7A:
undetectable
1c9sU-4wt7A:
undetectable		 1c9sT-4wt7A:
11.53
1c9sU-4wt7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.93A 1p7lD-4wt7A:
undetectable		 1p7lD-4wt7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.92A 1p7lC-4wt7A:
undetectable		 1p7lC-4wt7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.92A 1rg9C-4wt7A:
undetectable		 1rg9C-4wt7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		3 / 3 ALA A 238
VAL A 174
TRP A 240
 None
 0.97A 2izqA-4wt7A:
undetectable
2izqB-4wt7A:
undetectable		 2izqA-4wt7A:
5.50
2izqB-4wt7A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 1.00A 2vcvA-4wt7A:
undetectable		 2vcvA-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 0.99A 2vcvG-4wt7A:
3.0		 2vcvG-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 7 ALA A 299
LEU A 295
ALA A  67
PHE A  63
 None
None
None
X9X  A 401 (-3.5A)
 0.91A 2vcvL-4wt7A:
3.0		 2vcvL-4wt7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 4 ILE A 262
GLN A 247
ILE A 226
LEU A 276
 None
 1.34A 3dzyD-4wt7A:
undetectable		 3dzyD-4wt7A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 6 VAL A 133
LEU A 305
ILE A 119
ILE A 109
 None
 0.82A 3gcsA-4wt7A:
undetectable		 3gcsA-4wt7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		3 / 3 TRP A 240
ALA A 238
VAL A 174
 None
 0.92A 3l8lA-4wt7A:
undetectable
3l8lB-4wt7A:
undetectable		 3l8lA-4wt7A:
5.50
3l8lB-4wt7A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 247
VAL A 273
VAL A 277
ASP A 268
 None
None
None
X9X  A 401 (-2.7A)
 1.08A 3uy4A-4wt7A:
undetectable		 3uy4A-4wt7A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 ASP A 137
ASN A 151
ILE A 186
GLY A 139
SER A 143
 X9X  A 401 (-3.0A)
None
None
None
None
 1.50A 4djfB-4wt7A:
undetectable		 4djfB-4wt7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.83A 4ndnB-4wt7A:
undetectable		 4ndnB-4wt7A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.81A 4ndnD-4wt7A:
undetectable		 4ndnD-4wt7A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		3 / 3 SER A 164
ASP A 165
GLN A 326
 None
 0.95A 4oltA-4wt7A:
undetectable
4oltB-4wt7A:
undetectable		 4oltA-4wt7A:
21.92
4oltB-4wt7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		3 / 3 GLN A 326
SER A 164
ASP A 165
 None
 0.93A 4qwpA-4wt7A:
undetectable
4qwpB-4wt7A:
undetectable		 4qwpA-4wt7A:
22.46
4qwpB-4wt7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		3 / 3 ASP A  60
GLY A  58
ASP A  86
 None
 0.59A 4xdtA-4wt7A:
undetectable		 4xdtA-4wt7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 THR A 264
SER A 282
GLY A 249
ALA A 255
 None
 0.91A 5eevL-4wt7A:
undetectable
5eevV-4wt7A:
undetectable		 5eevL-4wt7A:
11.53
5eevV-4wt7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 THR A 264
SER A 282
GLY A 249
ALA A 255
 None
 0.91A 5eewL-4wt7A:
undetectable
5eewV-4wt7A:
undetectable		 5eewL-4wt7A:
11.53
5eewV-4wt7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 THR A 264
SER A 282
GLY A 249
ALA A 255
 None
 0.92A 5ef3L-4wt7A:
undetectable
5ef3V-4wt7A:
undetectable		 5ef3L-4wt7A:
11.53
5ef3V-4wt7A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 8 GLN A 111
ASP A 120
ILE A 119
ASP A  91
 None
 0.77A 5t8sA-4wt7A:
undetectable		 5t8sA-4wt7A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 LEU A  98
GLY A 114
PRO A 183
PHE A 178
THR A 115
 None
None
None
X9X  A 401 ( 4.6A)
None
 1.33A 5x6yC-4wt7A:
2.7		 5x6yC-4wt7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 5 TYR A 265
GLN A 247
GLY A 234
ILE A 166
 None
 1.26A 6debB-4wt7A:
5.7		 6debB-4wt7A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 GLY A  58
ALA A  57
ILE A 119
ILE A 136
PRO A 183
 None
 0.94A 6difB-4wt7A:
undetectable		 6difB-4wt7A:
15.65