SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wts BETA-1,3-GLUCANOSYLT
RANSFERASE
(Rhizomucor
miehei) 		4 / 8 VAL A 129
TYR A  61
VAL A 118
ILE A 127
 None
 0.78A 4aftD-4wtsA:
undetectable
4aftE-4wtsA:
undetectable		 4aftD-4wtsA:
23.89
4aftE-4wtsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4wts BETA-1,3-GLUCANOSYLT
RANSFERASE
(Rhizomucor
miehei) 		5 / 12 ASN A 152
PHE A 154
ASP A 133
ASP A 105
ARG A 238
 BGC  A 303 (-4.1A)
BGC  A 303 (-4.0A)
None
None
BGC  A 303 (-2.6A)
 1.41A 4djeA-4wtsA:
7.2		 4djeA-4wtsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4wts BETA-1,3-GLUCANOSYLT
RANSFERASE
(Rhizomucor
miehei) 		4 / 4 ASN A 152
LEU A 227
PHE A 245
TYR A 212
 BGC  A 303 (-4.1A)
None
BGC  A 303 ( 4.4A)
None
 1.35A 4u14A-4wtsA:
undetectable		 4u14A-4wtsA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4wts BETA-1,3-GLUCANOSYLT
RANSFERASE
(Rhizomucor
miehei) 		3 / 3 VAL A 134
ALA A 132
PHE A 138
 None
 0.91A 4z4iA-4wtsA:
undetectable		 4z4iA-4wtsA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4wts BETA-1,3-GLUCANOSYLT
RANSFERASE
(Rhizomucor
miehei) 		3 / 3 VAL A 134
ALA A 132
PHE A 138
 None
 0.89A 5js1A-4wtsA:
undetectable		 5js1A-4wtsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4wts BETA-1,3-GLUCANOSYLT
RANSFERASE
(Rhizomucor
miehei) 		4 / 6 VAL A 118
LEU A  79
LEU A  83
LEU A  62
 None
 0.90A 6f6sA-4wtsA:
undetectable
6f6sB-4wtsA:
undetectable		 6f6sA-4wtsA:
14.81
6f6sB-4wtsA:
13.09