SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wtv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 GLN A 257
GLU A 189
PHE A 362
ALA A 341
 ATP  A1201 (-3.1A)
None
None
None
 1.30A 1linA-4wtvA:
undetectable		 1linA-4wtvA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A1128
PHE A1152
LEU A1132
ALA A1129
ILE A1077
 None
 0.89A 2aclA-4wtvA:
undetectable
2aclE-4wtvA:
undetectable		 2aclA-4wtvA:
20.53
2aclE-4wtvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 LYS A 252
TYR A 134
PRO A 149
 None
 1.44A 2j9cC-4wtvA:
undetectable		 2j9cC-4wtvA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 6 GLY A 145
PRO A 205
LYS A 206
THR A 207
 None
ATP  A1201 ( 4.5A)
None
None
 1.31A 2m2oB-4wtvA:
undetectable		 2m2oB-4wtvA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 LEU A 293
LEU A 296
ASP A 297
TRP A 364
 None
 1.05A 2rlfA-4wtvA:
undetectable
2rlfB-4wtvA:
undetectable		 2rlfA-4wtvA:
6.49
2rlfB-4wtvA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 LEU A 293
LEU A 296
ASP A 297
TRP A 364
 None
 0.95A 2rlfB-4wtvA:
undetectable
2rlfC-4wtvA:
undetectable		 2rlfB-4wtvA:
6.49
2rlfC-4wtvA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 ILE A 109
ALA A 113
LEU A 212
PHE A 106
 None
 0.70A 2w9sE-4wtvA:
undetectable		 2w9sE-4wtvA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 7 SER A 214
TYR A 134
VAL A 136
ILE A 117
 None
 1.26A 2x45B-4wtvA:
undetectable		 2x45B-4wtvA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 8 THR A1033
TYR A1024
ILE A1016
SER A1035
 None
 1.14A 2xytH-4wtvA:
undetectable		 2xytH-4wtvA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ALA A1128
PHE A1152
LEU A1132
ALA A1129
ILE A1077
 None
 1.01A 3falC-4wtvA:
undetectable		 3falC-4wtvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ALA A1128
PHE A1152
LEU A1132
ALA A1129
ILE A1077
 None
 0.95A 3fc6A-4wtvA:
undetectable		 3fc6A-4wtvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		6 / 12 THR A 207
ALA A 192
ALA A 348
ALA A 342
SER A 255
ASP A 297
 None
 1.44A 3mg0Y-4wtvA:
undetectable
3mg0Z-4wtvA:
undetectable		 3mg0Y-4wtvA:
16.60
3mg0Z-4wtvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 8 ASN A1001
ILE A1002
ASN A1067
ASP A1071
 None
 1.04A 4d39A-4wtvA:
1.0		 4d39A-4wtvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 THR A1025
TYR A1017
GLU A1010
HIS A1030
 None
 1.08A 5ecnA-4wtvA:
undetectable		 5ecnA-4wtvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ARG A 313
ALA A 341
GLU A 261
ILE A 343
PHE A 259
 None
None
None
ATP  A1201 (-3.6A)
ATP  A1201 (-3.2A)
 1.50A 5i73A-4wtvA:
1.9		 5i73A-4wtvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 MET A1101
ALA A1073
VAL A1148
LEU A1120
VAL A1086
 None
 1.28A 5tudD-4wtvA:
undetectable		 5tudD-4wtvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 4 SER A 133
THR A 207
ASP A 196
ASP A 344
 ATP  A1201 (-2.9A)
None
None
ATP  A1201 (-2.7A)
 1.50A 5vimB-4wtvA:
undetectable		 5vimB-4wtvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 ALA A1128
PHE A1152
LEU A1132
ALA A1129
ILE A1077
 None
 0.97A 6a5zL-4wtvA:
undetectable		 6a5zL-4wtvA:
11.74