SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4wtx INTEGRIN BETA-4
(Homo
sapiens) 		4 / 4 THR A1632
LEU A1631
VAL A1606
LEU A1605
 None
 1.10A 1fbmB-4wtxA:
undetectable		 1fbmB-4wtxA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4wtx INTEGRIN BETA-4
(Homo
sapiens) 		4 / 6 LEU A1589
LEU A1605
VAL A1646
PHE A1620
 None
 1.15A 4uswA-4wtxA:
undetectable		 4uswA-4wtxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4wtx INTEGRIN BETA-4
(Homo
sapiens) 		5 / 12 LEU A1589
GLY A1660
GLU A1659
VAL A1646
GLY A1614
 None
 1.28A 5f9zA-4wtxA:
undetectable		 5f9zA-4wtxA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4wtx INTEGRIN BETA-4
(Homo
sapiens) 		5 / 12 LEU A1589
GLY A1660
GLU A1659
VAL A1646
GLY A1615
 None
 1.06A 5f9zA-4wtxA:
undetectable		 5f9zA-4wtxA:
13.35