SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 6 GLY A 349
TYR A 356
ALA A 354
GLU A 357
 None
 1.01A 1dmaB-4wu0A:
undetectable		 1dmaB-4wu0A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 8 LEU A  83
ASN A  78
ASP A  32
LEU A  31
 None
 1.04A 1e7cA-4wu0A:
undetectable		 1e7cA-4wu0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 8 TYR A   4
LEU A 348
LEU A   7
SER A  11
 None
 1.08A 1i7zA-4wu0A:
undetectable		 1i7zA-4wu0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 7 MET A  54
PHE A  57
ASN A  78
GLU A  26
 None
 1.23A 1t9wA-4wu0A:
undetectable		 1t9wA-4wu0A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 5 LEU A 132
GLY A 131
HIS A 119
ILE A 127
 None
 0.72A 1xf1A-4wu0A:
undetectable		 1xf1A-4wu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 6 LEU A 132
GLY A 131
HIS A 119
ILE A 127
 None
 0.75A 1xf1B-4wu0A:
undetectable		 1xf1B-4wu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		3 / 3 LYS A 346
TYR A  27
PRO A 345
 None
 1.14A 2j9cC-4wu0A:
undetectable		 2j9cC-4wu0A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 ILE A  12
LEU A 352
PHE A 351
LEU A   7
ILE A 303
 None
 1.03A 2w3vA-4wu0A:
undetectable		 2w3vA-4wu0A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 LEU A  29
GLY A  33
VAL A  37
LEU A 313
ILE A  12
 None
 0.83A 3h52A-4wu0A:
undetectable		 3h52A-4wu0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 LEU A  29
GLY A  33
VAL A  37
MET A   8
LEU A 313
 None
 1.33A 3h52A-4wu0A:
undetectable		 3h52A-4wu0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 8 ARG A 103
VAL A 143
ILE A 155
GLN A 158
 None
 0.97A 3remA-4wu0A:
undetectable		 3remA-4wu0A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 8 ARG A 103
VAL A 143
ILE A 155
GLN A 158
 None
 1.03A 3remB-4wu0A:
undetectable		 3remB-4wu0A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 6 ARG A 200
LEU A 348
PRO A 350
SER A 265
 None
 0.82A 3vlnA-4wu0A:
undetectable		 3vlnA-4wu0A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 7 TRP A 128
HIS A 119
TYR A 123
TYR A 334
 None
 1.47A 4a3uA-4wu0A:
undetectable		 4a3uA-4wu0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		3 / 3 TYR A  95
ASP A  55
ASP A  48
 None
 0.83A 4a6eA-4wu0A:
undetectable		 4a6eA-4wu0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		3 / 3 ASN A  79
TRP A  23
ASP A  32
 None
 1.18A 4a7tA-4wu0A:
undetectable
4a7tF-4wu0A:
undetectable		 4a7tA-4wu0A:
17.65
4a7tF-4wu0A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		3 / 3 GLY A 192
SER A 187
TRP A 186
 None
 0.59A 4e7cD-4wu0A:
undetectable		 4e7cD-4wu0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 ALA A 264
LEU A 348
PHE A 351
ILE A 311
ILE A 299
 None
 0.90A 4ej1A-4wu0A:
undetectable		 4ej1A-4wu0A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 LEU A 352
LEU A 353
ILE A  12
ILE A  17
LEU A 313
 None
 1.06A 4j24A-4wu0A:
undetectable		 4j24A-4wu0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 LEU A 352
LEU A 353
ILE A  12
ILE A  17
LEU A 313
 None
 1.05A 4j24B-4wu0A:
undetectable		 4j24B-4wu0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 GLY A 135
GLY A 131
ASP A 154
HIS A 109
ILE A 106
 None
 0.95A 4krhA-4wu0A:
undetectable		 4krhA-4wu0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 11 GLY A  28
LEU A  19
MET A  54
LYS A  81
ILE A  82
 None
 1.47A 4pghC-4wu0A:
undetectable		 4pghC-4wu0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 10 GLU A 344
VAL A 341
ILE A 340
TYR A 261
ILE A 336
 None
 1.39A 4qt2A-4wu0A:
undetectable		 4qt2A-4wu0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 ALA A 264
LEU A 348
PHE A 351
ILE A 311
ILE A 299
 None
 0.86A 4x5iA-4wu0A:
undetectable		 4x5iA-4wu0A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 ALA A 264
LEU A 348
PHE A 351
ILE A 311
ILE A 299
 None
 0.89A 4x5jA-4wu0A:
undetectable		 4x5jA-4wu0A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		3 / 3 TYR A 358
LYS A 296
LYS A 292
 None
 1.14A 5dbyA-4wu0A:
undetectable		 5dbyA-4wu0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 TYR A 334
ASN A  73
HIS A 119
ASP A 130
HIS A 176
 None
 1.24A 5dv4A-4wu0A:
undetectable		 5dv4A-4wu0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		3 / 3 ALA A  98
ASN A 101
LEU A 102
 None
 0.37A 5i1nB-4wu0A:
undetectable		 5i1nB-4wu0A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 9 LEU A 230
VAL A 278
LEU A 283
ILE A 270
ALA A 291
 None
 1.32A 5og9A-4wu0A:
0.8		 5og9A-4wu0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 7 TYR A  72
GLN A 158
HIS A 119
TYR A  67
 None
 1.27A 5ov9B-4wu0A:
undetectable		 5ov9B-4wu0A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 MET A   8
LEU A  29
LEU A  31
ILE A  17
LEU A  19
 None
 1.13A 5toaB-4wu0A:
undetectable		 5toaB-4wu0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 12 LEU A 283
LEU A 238
ALA A 294
ILE A 270
LYS A 246
 None
 1.32A 5xiwD-4wu0A:
undetectable		 5xiwD-4wu0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		5 / 10 ASP A 130
HIS A 119
TYR A  25
GLU A  26
GLU A 344
 None
 1.48A 6cggB-4wu0A:
undetectable		 6cggB-4wu0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 5 TYR A 335
GLN A 250
ASN A 260
LEU A 252
 None
 1.23A 6d8pA-4wu0A:
undetectable		 6d8pA-4wu0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 6 TRP A 204
LEU A  19
GLN A 250
GLU A 344
 None
 1.49A 6djzC-4wu0A:
undetectable		 6djzC-4wu0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4wu0 SIMILAR TO YTER
(BACILUS SUBTILIS)
(Clostridium
acetobutylicum) 		4 / 6 ASP A  21
ASN A  79
LEU A  31
PHE A  49
 None
 1.25A 6ekuA-4wu0A:
undetectable		 6ekuA-4wu0A:
18.92