SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		3 / 3 LEU A 106
SER A 109
ASN A 111
 None
 0.79A 1bx4A-4wuiA:
undetectable		 1bx4A-4wuiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		3 / 3 ALA A  60
HIS A  82
VAL A  58
 None
 0.51A 1lquB-4wuiA:
2.3		 1lquB-4wuiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		5 / 10 LEU A  68
ALA A  71
LEU A  57
ASP A  89
LEU A  81
 None
 1.01A 1yi4A-4wuiA:
undetectable		 1yi4A-4wuiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		5 / 12 LEU A 123
GLY A 153
ASP A 125
ALA A 126
ALA A 139
 None
CIT  A 301 (-3.4A)
None
None
None
 1.23A 2br4B-4wuiA:
undetectable		 2br4B-4wuiA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		4 / 6 LEU A 150
LEU A 121
PRO A 145
VAL A 114
 None
 1.12A 2dqyC-4wuiA:
undetectable		 2dqyC-4wuiA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		4 / 8 ARG A 148
GLU A 120
GLU A 119
ARG A 102
 None
 1.24A 4bqfB-4wuiA:
undetectable		 4bqfB-4wuiA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		3 / 3 TRP A 149
ARG A 144
LEU A 106
 None
 0.91A 5dbyA-4wuiA:
undetectable		 5dbyA-4wuiA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		4 / 5 VAL A 114
ARG A 102
GLY A 118
TYR A 117
 None
 1.34A 5x80A-4wuiA:
undetectable
5x80B-4wuiA:
undetectable		 5x80A-4wuiA:
26.20
5x80B-4wuiA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		4 / 5 GLY A 118
TYR A 117
VAL A 114
ARG A 102
 None
 1.32A 5x80C-4wuiA:
undetectable
5x80D-4wuiA:
undetectable		 5x80C-4wuiA:
26.20
5x80D-4wuiA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 4wui N-(5'-PHOSPHORIBOSYL
)ANTHRANILATE
ISOMERASE
(Jonesia
denitrificans) 		5 / 12 PHE A  97
ALA A  71
ALA A  19
ALA A  16
LEU A   8
 None
 1.23A 6aycA-4wuiA:
undetectable		 6aycA-4wuiA:
14.71