SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 5 HIS A 303
SER A 191
LEU A 105
GLY A 216
 None
 1.01A 1a4lB-4wumA:
undetectable		 1a4lB-4wumA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 8 GLY A 163
GLU A 192
SER A 338
PHE A 265
 None
 0.96A 1ax9A-4wumA:
undetectable		 1ax9A-4wumA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 1.00A 1epbA-4wumA:
undetectable		 1epbA-4wumA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.88A 1epbB-4wumA:
undetectable		 1epbB-4wumA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 11 VAL A 170
LEU A 173
ALA A 174
ALA A 178
THR A 145
 None
 0.88A 1jinA-4wumA:
undetectable		 1jinA-4wumA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 5 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.20A 1t88B-4wumA:
undetectable		 1t88B-4wumA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 7 GLY A 163
GLU A 192
SER A 338
PHE A 265
 None
 0.97A 2ackA-4wumA:
undetectable		 2ackA-4wumA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 5 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.21A 2m56A-4wumA:
undetectable		 2m56A-4wumA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 5 LEU A 173
LEU A 105
MET A 158
ARG A 112
 None
 1.03A 2oiqA-4wumA:
undetectable		 2oiqA-4wumA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 8 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 None
 0.74A 2w9sE-4wumA:
undetectable		 2w9sE-4wumA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 6 THR A 169
VAL A 170
GLU A 192
CYH A 190
 None
 1.19A 3b6rB-4wumA:
undetectable		 3b6rB-4wumA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 8 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.07A 3fhxB-4wumA:
undetectable		 3fhxB-4wumA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 5 ASP A 311
LEU A 310
ILE A 275
PRO A 272
 None
 1.12A 3s3vA-4wumA:
undetectable		 3s3vA-4wumA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 12 ALA A  17
LEU A 171
ILE A  22
LEU A 343
LEU A  20
 None
 1.22A 4j24D-4wumA:
undetectable		 4j24D-4wumA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 6 PHE A 373
LEU A 310
VAL A 313
VAL A 369
 None
 1.15A 4kkyX-4wumA:
undetectable		 4kkyX-4wumA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 12 ILE A 114
LEU A  20
GLY A 149
LEU A 144
THR A 145
 None
 1.15A 5byjA-4wumA:
undetectable		 5byjA-4wumA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		3 / 3 ARG A   8
ASN A 181
ASP A 227
 None
 0.83A 5gwxA-4wumA:
undetectable		 5gwxA-4wumA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 9 LEU A 370
ARG A 350
ILE A  19
GLU A 238
VAL A 240
 None
 1.05A 5igzA-4wumA:
undetectable		 5igzA-4wumA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 12 TYR A  39
PRO A  37
GLN A 212
SER A  63
CYH A  60
 None
 1.44A 5mqtA-4wumA:
undetectable		 5mqtA-4wumA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		5 / 12 GLY A 372
LEU A 267
GLY A 306
ASN A 336
ILE A 309
 None
 1.17A 5vopB-4wumA:
undetectable		 5vopB-4wumA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 7 PHE A 373
GLY A 374
GLY A 376
THR A 132
 None
 0.73A 5ybbB-4wumA:
undetectable		 5ybbB-4wumA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 8 ILE A 246
THR A 245
GLN A 244
THR A 169
 None
 1.10A 6c06C-4wumA:
undetectable		 6c06C-4wumA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4wum CHALCONE SYNTHASE
(Freesia
hybrid
cultivar) 		4 / 8 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.92A 6c06C-4wumA:
undetectable		 6c06C-4wumA:
undetectable