SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 GLY A  61
GLN A  60
MET A  74
VAL A  75
ARG A  81
 None
 1.38A 1z95A-4wutA:
undetectable		 1z95A-4wutA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 6 ALA A 261
LEU A 259
ALA A 223
THR A 222
 None
 0.92A 3b6hA-4wutA:
undetectable		 3b6hA-4wutA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 GLY A 274
GLY A 271
ILE A  29
LEU A  88
VAL A 111
 None
 0.98A 3nk7B-4wutA:
4.7		 3nk7B-4wutA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 5 TYR A 159
VAL A 170
SER A 158
GLY A 162
 FCB  A 404 (-4.3A)
None
None
None
 1.27A 3v4tA-4wutA:
undetectable
3v4tD-4wutA:
undetectable		 3v4tA-4wutA:
22.72
3v4tD-4wutA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		4 / 6 PRO A 188
GLY A 171
ALA A 161
GLU A 166
 None
 0.98A 4g0uA-4wutA:
undetectable		 4g0uA-4wutA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 9 ALA A  99
ILE A  86
VAL A  83
ALA A 106
ILE A 108
 None
 1.09A 4lbgB-4wutA:
5.5		 4lbgB-4wutA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 GLY A  61
GLN A  60
MET A  74
VAL A  75
ARG A  81
 None
 1.46A 4ojbA-4wutA:
undetectable		 4ojbA-4wutA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 GLY A  61
GLN A  60
MET A  74
VAL A  75
ARG A  81
 None
 1.45A 4okxA-4wutA:
undetectable		 4okxA-4wutA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 ILE A 215
ALA A 241
GLY A 187
GLY A 217
VAL A 205
 None
 1.06A 5i71A-4wutA:
undetectable		 5i71A-4wutA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)
(Agrobacterium
vitis) 		5 / 12 ILE A 215
ALA A 241
GLY A 187
GLY A 217
VAL A 205
 None
 1.04A 5i75A-4wutA:
undetectable		 5i75A-4wutA:
20.33