SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wuv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  95
ILE A  97
ALA A  36
LEU A  44
ILE A  59
 None
 1.11A 1bsxA-4wuvA:
undetectable		 1bsxA-4wuvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  95
ILE A  97
ALA A  36
LEU A  44
ILE A  59
 None
 1.12A 1bsxB-4wuvA:
undetectable		 1bsxB-4wuvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 VAL A 272
LEU A 273
ALA A 255
LEU A 259
ILE A 164
 None
 1.02A 1fk6A-4wuvA:
undetectable		 1fk6A-4wuvA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		3 / 3 ASN A  78
PHE A 151
VAL A  82
 None
 0.76A 1kijA-4wuvA:
undetectable		 1kijA-4wuvA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 4 SER A 167
ILE A 166
VAL A 275
THR A 241
 None
NAD  A 301 (-3.9A)
None
None
 1.16A 1u70A-4wuvA:
undetectable		 1u70A-4wuvA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  95
ILE A  97
ALA A  36
LEU A  44
ILE A  59
 None
 1.04A 2h79A-4wuvA:
undetectable		 2h79A-4wuvA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  86
ALA A  56
VAL A  55
THR A  71
PHE A 151
 None
None
None
NAD  A 301 (-4.8A)
None
 1.28A 2qo4A-4wuvA:
undetectable		 2qo4A-4wuvA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  86
ALA A  56
VAL A  55
THR A  71
PHE A 151
 None
None
None
NAD  A 301 (-4.8A)
None
 1.27A 2qo6A-4wuvA:
undetectable		 2qo6A-4wuvA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 GLY A  22
GLY A  24
LEU A  47
ASN A  72
VAL A  73
 NAD  A 301 (-3.1A)
NAD  A 301 (-3.8A)
NAD  A 301 (-3.8A)
NAD  A 301 (-2.8A)
NAD  A 301 (-3.6A)
 0.79A 3embA-4wuvA:
5.7		 3embA-4wuvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  95
ILE A  97
ALA A  36
LEU A  44
ILE A  59
 None
 1.04A 3gwsX-4wuvA:
undetectable		 3gwsX-4wuvA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 LEU A  13
GLY A  64
ALA A  66
ILE A  20
 None
 0.75A 3jusA-4wuvA:
undetectable		 3jusA-4wuvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 8 LEU A  13
GLY A  64
ALA A  66
ILE A  20
 None
 0.75A 3jusA-4wuvA:
undetectable		 3jusA-4wuvA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  95
ILE A  42
ALA A  40
THR A  38
LEU A 256
 None
 1.20A 3s79A-4wuvA:
undetectable		 3s79A-4wuvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 9 LEU A  74
GLY A 101
ALA A 100
ILE A 188
VAL A  73
 NAD  A 301 ( 4.2A)
NAD  A 301 (-2.8A)
NAD  A 301 ( 4.4A)
None
NAD  A 301 (-3.6A)
 0.94A 3u7sA-4wuvA:
undetectable		 3u7sA-4wuvA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 10 ILE A  95
ILE A  42
ALA A  40
THR A  38
LEU A 256
 None
 1.21A 4kq8A-4wuvA:
undetectable		 4kq8A-4wuvA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 VAL A 271
ILE A 164
LEU A 252
LEU A 259
ALA A 210
 None
 1.03A 4m11B-4wuvA:
undetectable		 4m11B-4wuvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A 166
ILE A 237
LEU A 223
GLY A 247
SER A 249
 NAD  A 301 (-3.9A)
None
None
None
None
 1.13A 4o1eA-4wuvA:
undetectable		 4o1eA-4wuvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A 166
ILE A 237
LEU A 223
GLY A 247
SER A 249
 NAD  A 301 (-3.9A)
None
None
None
None
 1.19A 4o1eB-4wuvA:
undetectable		 4o1eB-4wuvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		3 / 3 GLY A  24
ASP A  46
ASN A  72
 NAD  A 301 (-3.8A)
NAD  A 301 (-2.3A)
NAD  A 301 (-2.8A)
 0.51A 5jglA-4wuvA:
6.7		 5jglA-4wuvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 ILE A  95
ILE A  42
ALA A  40
THR A  38
LEU A 256
 None
 1.20A 5jkvA-4wuvA:
undetectable		 5jkvA-4wuvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 12 GLY A  22
GLY A  24
ASP A  46
ASN A  48
VAL A  73
 NAD  A 301 (-3.1A)
NAD  A 301 (-3.8A)
NAD  A 301 (-2.3A)
NAD  A 301 (-4.8A)
NAD  A 301 (-3.6A)
 0.61A 5wy0A-4wuvA:
5.3		 5wy0A-4wuvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		5 / 10 LEU A 253
ILE A 260
LEU A  13
ALA A   9
GLU A 250
 None
 1.16A 5y7pG-4wuvA:
undetectable		 5y7pG-4wuvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE
(Haemophilus
influenzae) 		4 / 5 TYR A 141
ASN A 165
THR A 192
LEU A 195
 EDO  A 302 (-4.3A)
None
None
None
 1.46A 6d8pA-4wuvA:
2.4		 6d8pA-4wuvA:
18.10