SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		3 / 3 TRP A 302
VAL A 291
TRP A 305
 None
 1.21A 1gmkC-4wv3A:
undetectable
1gmkD-4wv3A:
undetectable		 1gmkC-4wv3A:
5.86
1gmkD-4wv3A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		3 / 4 LYS A 398
ALA A 410
MET A 416
 None
 1.03A 1hk3A-4wv3A:
undetectable		 1hk3A-4wv3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 ALA A 272
ALA A 248
LEU A 215
SER A 253
ILE A 255
 None
 1.05A 1rg7A-4wv3A:
undetectable		 1rg7A-4wv3A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 ALA A 272
ALA A 248
SER A 253
ILE A 255
LEU A 287
 None
 1.08A 1rg7A-4wv3A:
undetectable		 1rg7A-4wv3A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 GLY A 337
ILE A 314
GLY A 316
ILE A 317
PRO A 342
 None
None
3UK  A 601 (-4.0A)
3UK  A 601 (-4.0A)
None
 0.91A 2nnkB-4wv3A:
undetectable		 2nnkB-4wv3A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 7 ILE A  15
ARG A  18
GLY A 200
TRP A 199
 None
 1.13A 2pnjB-4wv3A:
3.6		 2pnjB-4wv3A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		6 / 9 PHE A 220
ALA A 293
GLY A 318
HIS A 324
ILE A 325
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
3UK  A 601 (-2.5A)
 0.53A 2v7bA-4wv3A:
59.8		 2v7bA-4wv3A:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		6 / 9 PHE A 220
ALA A 293
GLY A 318
HIS A 324
ILE A 325
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
3UK  A 601 (-2.5A)
 0.53A 2v7bB-4wv3A:
59.9		 2v7bB-4wv3A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		3 / 3 ARG A 335
GLY A 337
SER A 425
 None
 0.56A 2xctB-4wv3A:
2.4		 2xctB-4wv3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 LEU A 287
ALA A 273
ALA A 304
GLY A 310
ILE A 255
 None
 1.07A 3c6gA-4wv3A:
undetectable		 3c6gA-4wv3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 GLY A 226
GLY A 225
SER A 237
ALA A 216
ASP A  69
 None
 1.20A 3i5uB-4wv3A:
2.9		 3i5uB-4wv3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		6 / 12 GLY A 200
GLY A 225
ARG A  18
ALA A  12
CYH A 170
ASP A  14
 None
 1.41A 3keeA-4wv3A:
undetectable		 3keeA-4wv3A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 VAL A 136
TYR A 145
GLU A 122
ILE A 121
TYR A  99
 None
 1.50A 3q5pA-4wv3A:
undetectable		 3q5pA-4wv3A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		3 / 3 THR A 178
ASP A 415
GLU A 295
 None
 0.85A 3qowA-4wv3A:
undetectable		 3qowA-4wv3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 5 ILE A 229
THR A 224
THR A 221
PHE A  77
 None
None
3UK  A 601 (-3.8A)
None
 1.17A 3snfA-4wv3A:
undetectable		 3snfA-4wv3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 10 GLY A 235
ALA A 236
ASP A 210
ILE A 229
LEU A  29
 None
 0.98A 3ttpA-4wv3A:
undetectable		 3ttpA-4wv3A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 10 GLY A 235
ALA A 236
ASP A 210
ILE A 229
LEU A  29
 None
 0.94A 3ttpB-4wv3A:
undetectable		 3ttpB-4wv3A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 9 GLY A 235
ALA A 236
ASP A 210
ILE A 229
LEU A  29
 None
 0.98A 3u7sB-4wv3A:
undetectable		 3u7sB-4wv3A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 7 PHE A 220
PHE A 222
THR A 320
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-4.4A)
3UK  A 601 (-3.6A)
3UK  A 601 (-2.5A)
 0.72A 3vnsA-4wv3A:
45.1		 3vnsA-4wv3A:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 4 PRO A 456
LEU A 417
ILE A 445
ARG A 509
 None
 1.34A 3w1wA-4wv3A:
3.8		 3w1wA-4wv3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 9 TYR A 264
THR A 212
LEU A 206
LEU A 204
GLY A 205
 None
 1.39A 4c9kA-4wv3A:
undetectable		 4c9kA-4wv3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 9 TYR A 264
THR A 212
LEU A 206
LEU A 204
GLY A 205
 None
 1.40A 4c9pA-4wv3A:
undetectable		 4c9pA-4wv3A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 7 ALA A 293
ILE A 317
GLY A 318
ILE A 325
 3UK  A 601 (-3.5A)
3UK  A 601 (-4.0A)
3UK  A 601 (-3.5A)
None
 0.33A 4eatA-4wv3A:
57.4		 4eatA-4wv3A:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 9 ALA A 293
ILE A 317
GLY A 318
HIS A 324
ILE A 325
 3UK  A 601 (-3.5A)
3UK  A 601 (-4.0A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
None
 0.30A 4eatB-4wv3A:
57.5		 4eatB-4wv3A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 5 LEU A 417
ASP A 415
ARG A 509
ILE A 507
 None
 1.49A 4mwrA-4wv3A:
undetectable		 4mwrA-4wv3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 GLY A 223
GLY A 225
LEU A 215
ALA A 266
THR A 268
 None
 0.98A 4uckB-4wv3A:
2.6		 4uckB-4wv3A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 PHE A 230
TRP A  73
PHE A 323
SER A 171
GLY A  89
 None
 1.03A 4ydqB-4wv3A:
3.1		 4ydqB-4wv3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 TYR A 264
PHE A 263
PHE A 213
THR A 212
THR A 254
 None
 1.42A 4z7fB-4wv3A:
0.0		 4z7fB-4wv3A:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		4 / 8 VAL A 251
PHE A 263
ALA A 266
GLY A 269
 None
 0.54A 4zjzA-4wv3A:
57.8		 4zjzA-4wv3A:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 GLY A 226
TRP A  73
PHE A 323
SER A 171
GLY A  89
 None
 1.13A 5f9zA-4wv3A:
undetectable		 5f9zA-4wv3A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		3 / 3 THR A 178
ASP A 415
GLU A 295
 None
 0.82A 5fa8A-4wv3A:
undetectable		 5fa8A-4wv3A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 ALA A 216
ALA A 214
PHE A 213
THR A 212
THR A 224
 None
 1.20A 5k9dA-4wv3A:
undetectable		 5k9dA-4wv3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 7 PHE A 220
PHE A 222
GLY A 318
HIS A 324
LYS A 506
 3UK  A 601 (-4.3A)
3UK  A 601 (-4.4A)
3UK  A 601 (-3.5A)
3UK  A 601 (-3.6A)
3UK  A 601 (-2.5A)
 0.97A 5n9xA-4wv3A:
45.1		 5n9xA-4wv3A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 10 TYR A 192
ILE A 229
LEU A 228
LEU A  65
ALA A  87
 None
 1.23A 5y7pB-4wv3A:
undetectable		 5y7pB-4wv3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4wv3 ANTHRANILATE-COA
LIGASE
(Stigmatella
aurantiaca) 		5 / 12 LEU A 228
LEU A  65
GLY A  89
ASN A 173
ILE A  80
 None
 1.14A 6qxsD-4wv3A:
undetectable		 6qxsD-4wv3A:
21.28