SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens) 		4 / 7 LEU A 123
TYR A 126
VAL B  39
ILE A 130
 None
 1.31A 3ik3B-4wv4A:
undetectable		 3ik3B-4wv4A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens) 		5 / 11 ALA A 146
ILE B  69
GLY B  73
ALA B  76
THR B  96
 None
 1.00A 3rukD-4wv4A:
undetectable		 3rukD-4wv4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens) 		4 / 7 ALA A 146
GLY B  73
ALA B  76
THR B  96
 None
 0.85A 4r1zB-4wv4A:
undetectable		 4r1zB-4wv4A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens) 		4 / 8 ILE B  93
PHE A 144
THR B  83
PRO B  88
 None
 1.15A 5x23A-4wv4B:
undetectable		 5x23A-4wv4B:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4wv4 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 10
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 8
(Homo
sapiens;
Homo
sapiens) 		4 / 7 THR B  96
ILE A 151
THR B  89
PHE A 144
 None
None
GOL  A 301 (-3.6A)
None
 0.88A 5zsfA-4wv4B:
undetectable
5zsfB-4wv4B:
undetectable		 5zsfA-4wv4B:
23.71
5zsfB-4wv4B:
23.71