SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 10 PHE A 230
PRO A 229
VAL A 177
VAL A 157
PRO A 178
 None
 1.49A 13gsA-4wvaA:
2.0		 13gsA-4wvaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 9 PHE A 230
PRO A 229
VAL A 177
VAL A 157
PRO A 178
 None
 1.49A 13gsB-4wvaA:
2.7		 13gsB-4wvaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR A  28
TRP A  32
ASP A  35
TRP A 355
GLU A 393
 TRS  A 501 (-3.7A)
TRS  A 501 (-4.5A)
TRS  A 501 (-3.0A)
None
TRS  A 501 (-3.7A)
 1.10A 1gahA-4wvaA:
20.2		 1gahA-4wvaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR A  28
TRP A  32
TYR A 349
TRP A 355
GLU A 393
 TRS  A 501 (-3.7A)
TRS  A 501 (-4.5A)
TRS  A 501 (-4.3A)
None
TRS  A 501 (-3.7A)
 1.13A 1gahA-4wvaA:
20.2		 1gahA-4wvaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		3 / 3 GLN A 242
TYR A 143
ARG A 140
 None
 0.94A 1gtbA-4wvaA:
3.0		 1gtbA-4wvaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 11 ILE A 156
VAL A 157
LEU A 142
THR A 102
ILE A 101
 None
 1.10A 1pkvA-4wvaA:
undetectable
1pkvB-4wvaA:
undetectable		 1pkvA-4wvaA:
11.82
1pkvB-4wvaA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 4 ASP A  60
LEU A  55
LEU A  58
LEU A  56
 None
 1.26A 1u18A-4wvaA:
undetectable		 1u18A-4wvaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 TYR A  28
TRP A  32
ASP A  35
TYR A 349
TRP A 355
 TRS  A 501 (-3.7A)
TRS  A 501 (-4.5A)
TRS  A 501 (-3.0A)
TRS  A 501 (-4.3A)
None
 1.02A 1ulvA-4wvaA:
8.7		 1ulvA-4wvaA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A 393
TYR A 394
GLN A 103
ASP A 189
 TRS  A 501 (-3.7A)
None
TRS  A 501 (-3.4A)
None
 1.42A 2cl5B-4wvaA:
undetectable		 2cl5B-4wvaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		6 / 12 TYR A  28
TRP A  32
ASP A  35
TYR A 349
TRP A 355
GLU A 393
 TRS  A 501 (-3.7A)
TRS  A 501 (-4.5A)
TRS  A 501 (-3.0A)
TRS  A 501 (-4.3A)
None
TRS  A 501 (-3.7A)
 1.17A 2f6dA-4wvaA:
18.9		 2f6dA-4wvaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 8 TYR A 207
ASP A 165
TYR A 204
TYR A 349
HIS A 192
 None
TRS  A 501 (-3.1A)
None
TRS  A 501 (-4.3A)
None
 1.27A 2ha2A-4wvaA:
undetectable		 2ha2A-4wvaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 207
ASP A 165
TYR A 204
HIS A 192
 None
TRS  A 501 (-3.1A)
None
None
 1.30A 2ha2B-4wvaA:
undetectable		 2ha2B-4wvaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 207
TRP A  32
TYR A 204
TYR A 349
 None
TRS  A 501 (-4.5A)
None
TRS  A 501 (-4.3A)
 1.16A 2ha2B-4wvaA:
undetectable		 2ha2B-4wvaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 207
TYR A 204
TYR A 349
HIS A 192
 None
None
TRS  A 501 (-4.3A)
None
 1.07A 2ha2B-4wvaA:
undetectable		 2ha2B-4wvaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 207
SER A 162
TYR A 185
VAL A 177
 None
 1.33A 2y05A-4wvaA:
undetectable
2y05B-4wvaA:
undetectable		 2y05A-4wvaA:
22.94
2y05B-4wvaA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A 176
SER A 228
PHE A 230
PRO A 173
 None
 1.02A 3jqaA-4wvaA:
undetectable		 3jqaA-4wvaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A 176
SER A 228
PHE A 230
PRO A 173
 None
 1.15A 3jqaB-4wvaA:
undetectable		 3jqaB-4wvaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A 176
SER A 228
PHE A 230
PRO A 173
 None
 0.98A 3jqaC-4wvaA:
undetectable		 3jqaC-4wvaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A 176
SER A 228
PHE A 230
PRO A 173
 None
 1.04A 3jqaD-4wvaA:
undetectable		 3jqaD-4wvaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A 104
ILE A 156
THR A 102
ILE A 101
 None
 0.98A 3p50A-4wvaA:
undetectable		 3p50A-4wvaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A 104
ILE A 156
THR A 102
ILE A 101
 None
 0.97A 3p50B-4wvaA:
undetectable		 3p50B-4wvaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A 104
ILE A 156
THR A 102
ILE A 101
 None
 0.98A 3p50C-4wvaA:
undetectable		 3p50C-4wvaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 7 PRO A 104
ILE A 156
THR A 102
ILE A 101
 None
 0.97A 3p50D-4wvaA:
undetectable		 3p50D-4wvaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 8 ALA A 239
PHE A 283
PHE A 303
ALA A 301
THR A 299
 None
 1.42A 3t3sF-4wvaA:
undetectable		 3t3sF-4wvaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 5 TRP A  32
GLY A  26
ALA A  24
PHE A  20
 TRS  A 501 (-4.5A)
None
None
None
 1.20A 3wqwA-4wvaA:
undetectable		 3wqwA-4wvaA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 ARG A 403
GLY A 404
ASP A 396
PRO A 353
 None
 0.64A 4lajA-4wvaA:
undetectable
4lajB-4wvaA:
undetectable		 4lajA-4wvaA:
17.66
4lajB-4wvaA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 ASP A 234
SER A 286
ALA A 301
SER A 300
 None
 1.15A 4lv9A-4wvaA:
undetectable
4lv9B-4wvaA:
undetectable		 4lv9A-4wvaA:
20.94
4lv9B-4wvaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 7 ASP A 234
SER A 286
ALA A 301
SER A 300
 None
 1.09A 4lv9A-4wvaA:
undetectable
4lv9B-4wvaA:
undetectable		 4lv9A-4wvaA:
20.94
4lv9B-4wvaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 412
ILE A  39
GLY A  42
ARG A  14
ASN A  15
 None
 1.07A 4obwD-4wvaA:
undetectable		 4obwD-4wvaA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 9 TRP A 265
VAL A 253
ALA A 244
THR A 109
ALA A 250
 None
 1.28A 4oqrA-4wvaA:
undetectable		 4oqrA-4wvaA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A 192
ASP A 189
ARG A 187
ARG A 188
 None
 1.10A 4uhxA-4wvaA:
undetectable		 4uhxA-4wvaA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 8 ASN A 357
PHE A  38
TRP A 418
TRP A 360
 None
 1.39A 5amkA-4wvaA:
undetectable		 5amkA-4wvaA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 TYR A 207
ASP A 165
TYR A 204
TYR A 349
 None
TRS  A 501 (-3.1A)
None
TRS  A 501 (-4.3A)
 1.16A 5e2iA-4wvaA:
undetectable		 5e2iA-4wvaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A 135
LEU A 142
PHE A  59
LEU A  33
 None
 0.82A 5gs4A-4wvaA:
undetectable		 5gs4A-4wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 135
LEU A 142
PHE A  59
LEU A  33
 None
 0.93A 5gtrA-4wvaA:
undetectable		 5gtrA-4wvaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4wva UNCHARACTERIZED
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  12
GLY A 407
VAL A  22
ARG A  17
THR A  21
 None
 1.08A 5o4yD-4wvaA:
undetectable
5o4yE-4wvaA:
undetectable		 5o4yD-4wvaA:
3.35
5o4yE-4wvaA:
15.93