SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 6 VAL A  14
VAL A  56
ILE A  66
ASN A 273
 None
 0.98A 1e06A-4wviA:
undetectable		 1e06A-4wviA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 ALA A  57
GLY A  62
ALA A 282
ILE A  39
HIS A  10
 None
 1.14A 1kxhA-4wviA:
undetectable		 1kxhA-4wviA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 7 VAL A 495
VAL A 438
ASP A 436
ILE A 488
 None
 0.97A 1p7rA-4wviA:
undetectable		 1p7rA-4wviA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 10 LEU A 198
LEU A 201
ILE A 167
GLU A 159
LEU A 157
 None
None
None
MAL  A 601 (-3.6A)
None
 1.20A 1wopA-4wviA:
undetectable		 1wopA-4wviA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 11 THR A  99
GLN A 331
ALA A 330
ALA A 309
ALA A 307
 None
 1.14A 2f16H-4wviA:
undetectable
2f16I-4wviA:
undetectable		 2f16H-4wviA:
19.24
2f16I-4wviA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 11 THR A  99
GLN A 331
ALA A 330
ALA A 309
ALA A 307
 None
 1.13A 2f16V-4wviA:
undetectable
2f16W-4wviA:
undetectable		 2f16V-4wviA:
19.24
2f16W-4wviA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 8 VAL A 521
VAL A 415
LEU A 392
THR A 391
 None
 0.88A 2gehA-4wviA:
undetectable		 2gehA-4wviA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 ALA A 270
LEU A 286
PHE A 285
VAL A 299
GLY A  22
 None
 1.11A 2ve3A-4wviA:
undetectable		 2ve3A-4wviA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 8 THR A  99
LEU A 291
ASP A 293
GLU A 117
 None
None
None
MAL  A 601 (-2.9A)
 1.08A 2zw9A-4wviA:
undetectable		 2zw9A-4wviA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 6 ALA A 194
LEU A 198
ALA A 352
THR A 351
 None
 0.89A 3b6hA-4wviA:
undetectable		 3b6hA-4wviA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 6 ALA A 194
LEU A 198
ALA A 352
THR A 351
 None
 0.93A 3b6hB-4wviA:
undetectable		 3b6hB-4wviA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 6 PHE A 264
ALA A 168
LEU A 253
PRO A 165
 None
 0.99A 3bgdA-4wviA:
undetectable		 3bgdA-4wviA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 7 VAL A 116
GLY A 306
PRO A 235
LYS A 311
 None
 0.75A 3bjwC-4wviA:
undetectable		 3bjwC-4wviA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 7 TYR A 456
GLY A 413
VAL A 438
LEU A 457
 None
 0.91A 3elzA-4wviA:
undetectable		 3elzA-4wviA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		9 / 12 ASP A  20
LYS A  21
GLU A  50
GLU A  51
ALA A  69
ASP A  71
GLU A 117
PRO A 160
TRP A 236
 MAL  A 601 (-3.0A)
MAL  A 601 (-2.6A)
None
None
MAL  A 601 (-3.3A)
MAL  A 601 (-2.8A)
MAL  A 601 (-2.9A)
MAL  A 601 (-3.5A)
MAL  A 601 ( 4.6A)
 0.29A 3jyrA-4wviA:
61.6		 3jyrA-4wviA:
61.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		6 / 7 ASN A  18
TRP A  68
GLU A 159
TYR A 161
MET A 336
TRP A 346
 MAL  A 601 (-4.4A)
MAL  A 601 (-4.4A)
MAL  A 601 (-3.6A)
MAL  A 601 (-3.9A)
MAL  A 601 ( 4.3A)
MAL  A 601 (-3.7A)
 0.24A 3jyrA-4wviA:
61.6		 3jyrA-4wviA:
61.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 VAL A 202
LEU A 166
GLY A 193
ALA A 194
LEU A 367
 None
 1.00A 3n8yB-4wviA:
undetectable		 3n8yB-4wviA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 9 ILE A 138
LEU A 204
LYS A 262
ILE A 232
GLY A 197
 None
 1.23A 3sj4X-4wviA:
undetectable		 3sj4X-4wviA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 PHE A 162
GLY A 306
LEU A 305
GLU A 117
ALA A 237
 None
None
None
MAL  A 601 (-2.9A)
None
 0.86A 3tbgB-4wviA:
undetectable		 3tbgB-4wviA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 PHE A 162
GLY A 306
LEU A 305
GLU A 117
ALA A 237
 None
None
None
MAL  A 601 (-2.9A)
None
 0.84A 3tbgD-4wviA:
undetectable		 3tbgD-4wviA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 ALA A 237
TYR A  23
TYR A 216
ASN A 240
GLY A 234
 None
 1.41A 3vwqA-4wviA:
undetectable		 3vwqA-4wviA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 11 ALA A 237
ASP A 302
TYR A 216
ASN A 240
GLY A 234
 None
 1.30A 3vwrA-4wviA:
undetectable		 3vwrA-4wviA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 5 GLU A 314
ASP A 320
ASP A 293
ASN A 300
 None
 1.36A 3vywD-4wviA:
undetectable		 3vywD-4wviA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		3 / 3 LYS A 148
LEU A 145
ALA A 147
 None
 0.69A 4ikiA-4wviA:
undetectable		 4ikiA-4wviA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 LEU A 494
TYR A 456
GLY A 497
ARG A 500
THR A 470
 None
 1.21A 4o5fA-4wviA:
undetectable
4o5fB-4wviA:
undetectable		 4o5fA-4wviA:
21.25
4o5fB-4wviA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 9 ALA A 270
ALA A 111
LEU A 109
LEU A 268
VAL A 267
 None
 1.14A 4or0B-4wviA:
undetectable		 4or0B-4wviA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		4 / 7 TYR A 440
TYR A 456
LEU A 457
GLN A 452
 None
 1.33A 4qzuB-4wviA:
undetectable		 4qzuB-4wviA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		5 / 12 TYR A 456
GLY A 497
ARG A 500
THR A 470
LEU A 494
 None
 1.19A 5b8hA-4wviA:
undetectable
5b8hB-4wviA:
undetectable		 5b8hA-4wviA:
20.15
5b8hB-4wviA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		6 / 12 ALA A 348
ALA A 344
GLY A 172
ALA A 194
PHE A 175
VAL A 187
 None
 1.40A 5w4zA-4wviA:
undetectable		 5w4zA-4wviA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		6 / 12 ALA A 348
ALA A 344
GLY A 172
ALA A 194
PHE A 175
VAL A 187
 None
 1.43A 5w4zB-4wviA:
undetectable		 5w4zB-4wviA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB
(Escherichia
coli;
Staphylococcus
aureus) 		3 / 3 TYR A 161
ASN A 233
LEU A 119
 MAL  A 601 (-3.9A)
None
None
 0.83A 6b58A-4wviA:
undetectable		 6b58A-4wviA:
22.01