SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		3 / 3 GLN A 296
TYR A  98
ARG A 284
 None
 0.87A 1gtbA-4wvmA:
undetectable		 1gtbA-4wvmA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		5 / 11 MET A   7
PRO A   8
LEU A  10
ASN A 265
VAL A 269
 None
 1.50A 1mrlA-4wvmA:
undetectable
1mrlB-4wvmA:
undetectable		 1mrlA-4wvmA:
14.56
1mrlB-4wvmA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		5 / 12 MET A   7
PRO A   8
LEU A  10
ASN A 265
VAL A 269
 None
 1.32A 1mrlB-4wvmA:
undetectable
1mrlC-4wvmA:
undetectable		 1mrlB-4wvmA:
14.56
1mrlC-4wvmA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 5 GLU B 345
LEU B 339
LEU B 342
LEU B 340
 None
 1.08A 1np1A-4wvmB:
undetectable		 1np1A-4wvmB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 6 GLY B 170
ILE B 168
GLN B 171
VAL B 175
 None
 1.05A 1rs7B-4wvmB:
undetectable		 1rs7B-4wvmB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 4 THR A 105
GLY A 208
ASP A 209
ALA A  89
 None
 0.91A 1sg9A-4wvmA:
2.4		 1sg9A-4wvmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 4 THR B 106
GLY B 209
ASP B 210
ALA B  90
 None
 0.97A 1sg9A-4wvmB:
undetectable		 1sg9A-4wvmB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 MET B  69
ASN B  95
GLN B  96
 None
 1.05A 1xoqB-4wvmB:
undetectable		 1xoqB-4wvmB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		5 / 12 GLY B  82
GLY B  81
VAL B 271
SER B  74
LEU B  93
 None
 1.25A 1ya4B-4wvmB:
undetectable		 1ya4B-4wvmB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 6 LEU A 453
LYS A 454
ARG A 458
GLY A 489
 None
 1.25A 2hs2B-4wvmA:
undetectable		 2hs2B-4wvmA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 ASN B 368
ARG B 371
ASP B 161
 None
 0.92A 2qe6A-4wvmB:
undetectable		 2qe6A-4wvmB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 ASN B 368
ARG B 371
ASP B 161
 None
 0.86A 2qe6B-4wvmB:
undetectable		 2qe6B-4wvmB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		5 / 12 LEU A  10
GLY A  86
SER A  88
SER A  77
GLY A  75
 None
 1.24A 2vmyB-4wvmA:
undetectable		 2vmyB-4wvmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		5 / 12 ILE A 536
ALA A 549
LEU A 702
PHE A 689
ARG A 603
 None
 1.29A 2w3mB-4wvmA:
undetectable		 2w3mB-4wvmA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		5 / 12 ILE A 167
TYR A 226
PHE A 152
PHE A 210
ALA A 148
 None
 1.36A 2x2nD-4wvmA:
undetectable		 2x2nD-4wvmA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		5 / 12 ILE B 168
TYR B 227
PHE B 153
PHE B 211
ALA B 149
 None
 1.33A 2x2nD-4wvmB:
undetectable		 2x2nD-4wvmB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 6 ASN A 474
SER A 472
ALA A 526
ASP A 528
 None
 1.25A 3aruA-4wvmA:
2.0		 3aruA-4wvmA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 PHE B 307
CYH B 311
PHE B 351
 None
 1.01A 3cr5X-4wvmB:
undetectable		 3cr5X-4wvmB:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 6 LEU B 700
GLN B 696
LEU B 581
GLU B 582
 None
 1.02A 3h5gB-4wvmB:
undetectable
3h5gC-4wvmB:
undetectable		 3h5gB-4wvmB:
3.30
3h5gC-4wvmB:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 8 PHE B 211
ALA B 149
ALA B 111
LEU A 215
 None
 0.89A 3l4dD-4wvmB:
2.6		 3l4dD-4wvmB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 VAL B   8
VAL B  84
SER B  78
 None
 0.73A 3n8xB-4wvmB:
undetectable		 3n8xB-4wvmB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 6 GLY B 170
ILE B 168
GLN B 171
VAL B 175
 None
 1.08A 4d39B-4wvmB:
undetectable		 4d39B-4wvmB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 6 GLY B 170
ILE B 168
GLN B 171
VAL B 175
 None
 1.11A 4kcnA-4wvmB:
undetectable		 4kcnA-4wvmB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		6 / 9 LEU B 230
ALA B 151
LEU B 107
PHE B 153
THR B 226
LEU B 213
 None
 1.49A 4ltwA-4wvmB:
undetectable		 4ltwA-4wvmB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 ASP B 415
LEU B 418
PHE B 417
 None
 0.73A 4pthA-4wvmB:
undetectable		 4pthA-4wvmB:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 8 ILE A 311
LEU A 419
TYR A 418
LEU A 361
 None
 0.83A 4qopC-4wvmA:
undetectable		 4qopC-4wvmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 6 TYR A 495
THR A 480
GLN A 389
LEU A 500
 None
 0.97A 4qzuC-4wvmA:
undetectable		 4qzuC-4wvmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		5 / 9 ALA A 481
VAL A 452
GLY A 489
ILE A 298
VAL A 370
 None
 1.06A 4r21B-4wvmA:
3.4		 4r21B-4wvmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 7 GLY A 595
GLY A 613
TYR A 598
ALA A 688
 None
 1.00A 5e26A-4wvmA:
undetectable
5e26B-4wvmA:
undetectable		 5e26A-4wvmA:
21.45
5e26B-4wvmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		3 / 3 HIS B 670
LYS B 624
PHE B 616
 None
 1.34A 5klaA-4wvmB:
undetectable		 5klaA-4wvmB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
(Synanceia
horrida) 		4 / 8 GLU A  52
GLN A  48
LEU A 145
THR A 112
 None
 1.05A 5syjA-4wvmA:
undetectable		 5syjA-4wvmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4wvm STONUSTOXIN SUBUNIT
ALPHA
STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida;
Synanceia
horrida) 		5 / 12 GLY A 208
LEU A 211
GLY B 148
PRO A  13
GLY A  11
 None
 1.22A 5tuiB-4wvmA:
undetectable		 5tuiB-4wvmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4wvm STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida) 		4 / 4 HIS B 140
VAL B   8
LEU B   6
ALA B  23
 None
 1.28A 6d8pB-4wvmB:
undetectable		 6d8pB-4wvmB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4wvm STONUSTOXIN SUBUNIT
ALPHA
STONUSTOXIN SUBUNIT
BETA
(Synanceia
horrida;
Synanceia
horrida) 		4 / 6 ASP B 650
TYR B 522
GLU B 466
GLU A 587
 None
 1.41A 6mn5C-4wvmB:
undetectable		 6mn5C-4wvmB:
7.69