SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wvw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4wvw GALECTIN
(Gallus
gallus) 		4 / 5 LEU A 137
VAL A  19
TYR A  18
THR A 136
 None
 1.46A 1nw3A-4wvwA:
undetectable		 1nw3A-4wvwA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wvw GALECTIN
(Gallus
gallus) 		3 / 3 VAL A  61
ALA A  62
HIS A 127
 None
 0.64A 1q23J-4wvwA:
undetectable		 1q23J-4wvwA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4wvw GALECTIN
(Gallus
gallus) 		4 / 7 CYH A  77
PHE A  45
PHE A  63
LEU A 137
 None
 1.04A 1qcaA-4wvwA:
undetectable		 1qcaA-4wvwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 GLY A 138
GLY A  20
ILE A 148
SER A  53
PRO A  17
 None
 0.81A 1sg9B-4wvwA:
undetectable		 1sg9B-4wvwA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 11 LEU A  26
VAL A  61
GLN A  50
ILE A  32
LEU A  34
 None
 1.26A 2q6hA-4wvwA:
undetectable		 2q6hA-4wvwA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 ILE A  16
ILE A  11
SER A  12
LEU A  34
ILE A 139
 None
 0.95A 3cd2A-4wvwA:
undetectable		 3cd2A-4wvwA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4wvw GALECTIN
(Gallus
gallus) 		6 / 6 HIS A  64
ASN A  66
ARG A  68
ASN A  78
TRP A  85
GLU A  88
 SLT  A 201 (-3.9A)
SLT  A 201 (-3.8A)
SLT  A 201 (-2.7A)
SLT  A 201 (-3.9A)
SLT  A 201 (-3.6A)
SLT  A 201 (-2.8A)
 0.29A 3galA-4wvwA:
24.0		 3galA-4wvwA:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4wvw GALECTIN
(Gallus
gallus) 		4 / 6 HIS A  64
ASN A  66
ARG A  44
TRP A  85
 SLT  A 201 (-3.9A)
SLT  A 201 (-3.8A)
SLT  A 201 (-2.9A)
SLT  A 201 (-3.6A)
 1.24A 3galB-4wvwA:
23.6		 3galB-4wvwA:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 4wvw GALECTIN
(Gallus
gallus) 		6 / 6 HIS A  64
ASN A  66
ARG A  68
ASN A  78
TRP A  85
GLU A  88
 SLT  A 201 (-3.9A)
SLT  A 201 (-3.8A)
SLT  A 201 (-2.7A)
SLT  A 201 (-3.9A)
SLT  A 201 (-3.6A)
SLT  A 201 (-2.8A)
 0.32A 3galB-4wvwA:
23.6		 3galB-4wvwA:
35.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 11 VAL A  61
HIS A  64
GLN A  46
VAL A  19
TYR A 140
 None
SLT  A 201 (-3.9A)
SLT  A 201 (-3.4A)
None
None
 1.47A 3mbhA-4wvwA:
undetectable		 3mbhA-4wvwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 VAL A  61
HIS A  64
GLN A  46
VAL A  19
TYR A 140
 None
SLT  A 201 (-3.9A)
SLT  A 201 (-3.4A)
None
None
 1.44A 3mbhB-4wvwA:
undetectable		 3mbhB-4wvwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 VAL A  61
HIS A  64
GLN A  46
VAL A  19
TYR A 140
 None
SLT  A 201 (-3.9A)
SLT  A 201 (-3.4A)
None
None
 1.42A 3mbhC-4wvwA:
undetectable		 3mbhC-4wvwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 VAL A  61
HIS A  64
GLN A  46
VAL A  19
TYR A 140
 None
SLT  A 201 (-3.9A)
SLT  A 201 (-3.4A)
None
None
 1.45A 3mbhD-4wvwA:
undetectable		 3mbhD-4wvwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 VAL A  61
HIS A  64
GLN A  46
VAL A  19
TYR A 140
 None
SLT  A 201 (-3.9A)
SLT  A 201 (-3.4A)
None
None
 1.44A 3mbhE-4wvwA:
undetectable		 3mbhE-4wvwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wvw GALECTIN
(Gallus
gallus) 		4 / 4 LYS A 112
PHE A 113
PHE A  65
VAL A  75
 None
 1.30A 3rv5A-4wvwA:
undetectable
3rv5B-4wvwA:
undetectable		 3rv5A-4wvwA:
16.44
3rv5B-4wvwA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 11 LEU A  26
ALA A  62
ASP A  60
ILE A  22
ILE A 134
 None
 1.14A 3s53B-4wvwA:
undetectable		 3s53B-4wvwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4wvw GALECTIN
(Gallus
gallus) 		5 / 12 ILE A 104
ILE A  22
LEU A 137
PHE A  63
ILE A 148
 None
 1.06A 5mugA-4wvwA:
undetectable		 5mugA-4wvwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4wvw GALECTIN
(Gallus
gallus) 		6 / 7 HIS A  64
ASN A  66
ARG A  68
ASN A  78
TRP A  85
GLU A  88
 SLT  A 201 (-3.9A)
SLT  A 201 (-3.8A)
SLT  A 201 (-2.7A)
SLT  A 201 (-3.9A)
SLT  A 201 (-3.6A)
SLT  A 201 (-2.8A)
 0.15A 6b8kA-4wvwA:
23.9		 6b8kA-4wvwA:
26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 4wvw GALECTIN
(Gallus
gallus) 		6 / 8 HIS A  64
ASN A  66
ARG A  68
ASN A  78
TRP A  85
GLU A  88
 SLT  A 201 (-3.9A)
SLT  A 201 (-3.8A)
SLT  A 201 (-2.7A)
SLT  A 201 (-3.9A)
SLT  A 201 (-3.6A)
SLT  A 201 (-2.8A)
 0.38A 6b94A-4wvwA:
19.3		 6b94A-4wvwA:
32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 4wvw GALECTIN
(Gallus
gallus) 		6 / 10 HIS A  64
ASN A  66
ARG A  68
ASN A  78
TRP A  85
GLU A  88
 SLT  A 201 (-3.9A)
SLT  A 201 (-3.8A)
SLT  A 201 (-2.7A)
SLT  A 201 (-3.9A)
SLT  A 201 (-3.6A)
SLT  A 201 (-2.8A)
 0.34A 6b94A-4wvwA:
19.3
6b94B-4wvwA:
18.9		 6b94A-4wvwA:
32.61
6b94B-4wvwA:
32.61