SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ww5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121
(Saccharomyces
cerevisiae) 		3 / 3 GLU B  77
THR B  60
LEU B 107
 None
 0.70A 1v8bC-4ww5B:
undetectable		 1v8bC-4ww5B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121
(Saccharomyces
cerevisiae) 		4 / 7 ILE B  12
LEU B 107
THR B  71
ARG B 179
 None
 1.08A 3nxuA-4ww5B:
undetectable		 3nxuA-4ww5B:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121
(Saccharomyces
cerevisiae) 		4 / 7 SER B 157
ASP B 174
ARG B 170
GLY B 167
 None
 0.95A 5btfA-4ww5B:
2.0
5btfB-4ww5B:
undetectable
5btfC-4ww5B:
1.9		 5btfA-4ww5B:
16.89
5btfB-4ww5B:
24.32
5btfC-4ww5B:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121
(Saccharomyces
cerevisiae) 		4 / 7 ILE B  12
LEU B 107
THR B  71
ARG B 179
 None
 1.01A 5vc0A-4ww5B:
undetectable		 5vc0A-4ww5B:
17.66