SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ww7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  30
LYS A  52
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.42A 3warA-4ww7A:
5.9		 3warA-4ww7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 4 PRO A  92
LEU A 106
ILE A 104
ARG A  54
 AMP  A 301 ( 4.7A)
AMP  A 301 ( 4.4A)
None
None
 1.36A 4f4dA-4ww7A:
undetectable		 4f4dA-4ww7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  30
LYS A  52
LEU A 106
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.4A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.53A 4iaaA-4ww7A:
11.9		 4iaaA-4ww7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 4 ASP A 161
LEU A 185
ARG A  54
THR A 163
 None
 1.47A 4kjkA-4ww7A:
undetectable		 4kjkA-4ww7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 206
SER A 164
ASP A 130
ASP A 132
 None
 1.44A 4krhB-4ww7A:
undetectable		 4krhB-4ww7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 161
LEU A 185
ARG A  54
THR A 163
 None
 1.49A 4p3qA-4ww7A:
undetectable		 4p3qA-4ww7A:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WW7_A_ACTA302_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		5 / 5 PRO A 114
MET A 128
HIS A 129
LEU A 137
TRP A 176
 ACT  A 302 ( 4.8A)
ACT  A 302 ( 4.5A)
ACT  A 302 (-4.1A)
None
ACT  A 302 (-4.3A)
 0.00A 4ww7A-4ww7A:
40.9		 4ww7A-4ww7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 191
VAL A 192
GLU A 193
ARG A 246
 ACT  A 303 (-3.6A)
ACT  A 303 (-3.0A)
None
ACT  A 303 (-4.0A)
 0.02A 4ww7A-4ww7A:
40.9		 4ww7A-4ww7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		6 / 6 LEU A 199
LEU A 202
GLU A 203
ASN A 218
ILE A 221
MET A 222
 ACT  A 305 (-4.1A)
ACT  A 305 ( 4.1A)
None
ACT  A 305 (-3.5A)
ACT  A 305 ( 3.7A)
ACT  A 305 (-3.5A)
 0.00A 4ww7A-4ww7A:
40.9		 4ww7A-4ww7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 107
THR A 177
HIS A 179
 None
 0.81A 4ydqB-4ww7A:
undetectable		 4ydqB-4ww7A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 8 VAL A  30
LYS A  52
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.43A 5y9mX-4ww7A:
6.5		 5y9mX-4ww7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  30
LYS A  52
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.53A 5yf9B-4ww7A:
9.6		 5yf9B-4ww7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  30
LYS A  52
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.56A 5ywmX-4ww7A:
6.7		 5ywmX-4ww7A:
17.14