SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A
(Homo
sapiens;
Homo
sapiens) 		5 / 11 HIS B 106
LEU B 119
LEU A1079
VAL A1088
ILE B  99
 None
 1.30A 1ee2A-4wwrB:
undetectable		 1ee2A-4wwrB:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A
(Homo
sapiens;
Homo
sapiens) 		5 / 11 HIS B 106
LEU B 119
LEU A1079
VAL A1088
ILE B  99
 None
 1.29A 1ee2B-4wwrB:
undetectable		 1ee2B-4wwrB:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		4 / 7 LEU A1079
GLU A1084
LEU B 119
ALA A1065
 None
 1.07A 1sn0B-4wwrA:
undetectable
1sn0D-4wwrA:
undetectable		 1sn0B-4wwrA:
18.26
1sn0D-4wwrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A
(Homo
sapiens;
Homo
sapiens) 		4 / 8 TYR B 123
TRP B  96
TYR A1092
ILE B  99
 None
 1.22A 4bqtC-4wwrB:
undetectable
4bqtD-4wwrB:
undetectable		 4bqtC-4wwrB:
16.15
4bqtD-4wwrB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4wwr LARGE PROLINE-RICH
PROTEIN BAG6
UBIQUITIN-LIKE
PROTEIN 4A
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG B 125
SER B 126
ALA A1060
ALA A1067
 None
 1.13A 6ma6A-4wwrB:
undetectable		 6ma6A-4wwrB:
13.75