SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 6 LYS A 348
LEU A 345
GLU A 352
ALA A 195
 None
 1.23A 1etb2-4wwvA:
undetectable		 1etb2-4wwvA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 11 HIS A 329
LEU A 218
GLU A 214
ILE A  74
GLU A 215
 None
 1.32A 1rnrA-4wwvA:
undetectable		 1rnrA-4wwvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 12 HIS A 329
LEU A 218
GLU A 214
ILE A  74
GLU A 215
 None
 1.29A 1rnrB-4wwvA:
undetectable		 1rnrB-4wwvA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 5 ASP A 231
GLY A  61
ALA A 354
ILE A 359
 None
 0.77A 2aofA-4wwvA:
undetectable		 2aofA-4wwvA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 7 VAL A 165
ILE A 119
GLN A 103
GLY A 120
 None
 0.87A 3bjwB-4wwvA:
undetectable		 3bjwB-4wwvA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 12 GLU A 214
THR A 304
ASP A 184
GLY A  94
HIS A 329
 None
 1.32A 3ce6D-4wwvA:
undetectable		 3ce6D-4wwvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 12 TYR A 341
GLU A 352
ILE A 351
ALA A 349
ILE A  67
 None
 1.35A 3ndiA-4wwvA:
undetectable		 3ndiA-4wwvA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 5 VAL A 106
VAL A 105
ARG A 116
LYS A 181
 None
 1.46A 3rv5A-4wwvA:
undetectable
3rv5B-4wwvA:
undetectable		 3rv5A-4wwvA:
14.11
3rv5B-4wwvA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 7 ASP A 184
GLU A 215
HIS A 329
GLU A 214
 None
 0.90A 4hvrA-4wwvA:
undetectable		 4hvrA-4wwvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		7 / 11 HIS A  70
ASP A 184
GLU A 214
GLU A 215
GLY A 267
GLY A 302
HIS A 329
 None
 1.25A 4pqaA-4wwvA:
23.3		 4pqaA-4wwvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		8 / 11 HIS A  70
ASP A 184
GLU A 214
GLU A 215
GLY A 301
GLY A 302
ILE A 328
HIS A 329
 None
 0.84A 4pqaA-4wwvA:
23.3		 4pqaA-4wwvA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 11 GLY A 319
ILE A 309
GLY A 188
ILE A  67
PHE A 350
 None
 1.03A 4qoiA-4wwvA:
2.2
4qoiB-4wwvA:
2.6		 4qoiA-4wwvA:
21.46
4qoiB-4wwvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 4 LEU A 173
ARG A   6
ILE A 178
ILE A  10
 None
 1.40A 5dzk2-4wwvA:
undetectable
5dzkM-4wwvA:
undetectable
5dzkN-4wwvA:
undetectable		 5dzk2-4wwvA:
1.57
5dzkM-4wwvA:
20.10
5dzkN-4wwvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 7 VAL A 209
GLY A 220
ALA A 221
SER A 224
 None
 0.83A 5f1aB-4wwvA:
undetectable		 5f1aB-4wwvA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 12 VAL A 187
PRO A 260
ALA A 343
VAL A 191
ILE A 299
 None
 1.07A 5hv1A-4wwvA:
undetectable		 5hv1A-4wwvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		4 / 6 VAL A 106
SER A  18
ARG A 186
ILE A  13
 None
 1.08A 5jw1B-4wwvA:
undetectable		 5jw1B-4wwvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 10 LEU A  36
VAL A  29
VAL A 189
VAL A  52
ALA A 210
 None
 1.03A 6czmA-4wwvA:
undetectable
6czmC-4wwvA:
undetectable		 6czmA-4wwvA:
25.00
6czmC-4wwvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4wwv AMINOPEPTIDASE FROM
FAMILY M42
(Desulfurococcus
amylolyticus) 		5 / 12 THR A 320
GLY A 319
VAL A 316
THR A 239
ASP A 184
 None
 1.16A 6gngA-4wwvA:
undetectable		 6gngA-4wwvA:
25.53