SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.43A 1bcuH-4wwyA:
18.4		 1bcuH-4wwyA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.48A 1dwcH-4wwyA:
33.7		 1dwcH-4wwyA:
36.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 9 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.20A 1eqgA-4wwyA:
undetectable		 1eqgA-4wwyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 11 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.20A 1eqgB-4wwyA:
undetectable		 1eqgB-4wwyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 12 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.17A 1eqhA-4wwyA:
undetectable		 1eqhA-4wwyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 12 VAL A  52
LEU A  67
ILE A  63
ALA A  85
SER A 109
LEU A 108
 None
 1.16A 1eqhB-4wwyA:
undetectable		 1eqhB-4wwyA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		8 / 12 HIS A  57
LEU A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.70A 1etrH-4wwyA:
33.9		 1etrH-4wwyA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.37A 1f5lA-4wwyA:
15.7		 1f5lA-4wwyA:
37.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4wwy TRYPSIN-1
(Homo
sapiens) 		4 / 7 SER A  32
GLU A  70
GLU A  77
GLU A 154
 None
 1.12A 1knyA-4wwyA:
undetectable
1knyB-4wwyA:
undetectable		 1knyA-4wwyA:
20.00
1knyB-4wwyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4wwy TRYPSIN-1
(Homo
sapiens) 		4 / 8 GLU A 154
SER A  32
GLU A  70
GLU A  77
 None
 1.15A 1knyA-4wwyA:
undetectable
1knyB-4wwyA:
undetectable		 1knyA-4wwyA:
20.00
1knyB-4wwyA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.25A 1tnlA-4wwyA:
42.0		 1tnlA-4wwyA:
74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.22A 2otvA-4wwyA:
42.0		 2otvA-4wwyA:
74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4wwy TRYPSIN-1
(Homo
sapiens) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.34A 2p16A-4wwyA:
35.9		 2p16A-4wwyA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 None
 0.37A 2w26A-4wwyA:
13.9		 2w26A-4wwyA:
35.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 12 GLY A  56
TYR A 234
SER A 195
HIS A  57
TRP A 215
 None
 1.06A 2zthA-4wwyA:
undetectable		 2zthA-4wwyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 9 LEU A  99
ASP A 102
GLY A  56
ALA A  55
VAL A 213
 None
 1.05A 3ektA-4wwyA:
undetectable		 3ektA-4wwyA:
24.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		9 / 11 HIS A  57
LEU A  99
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.59A 3gy3A-4wwyA:
41.2		 3gy3A-4wwyA:
74.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 12 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 1.00A 3pghC-4wwyA:
undetectable		 3pghC-4wwyA:
16.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.32A 3rxfA-4wwyA:
42.3		 3rxfA-4wwyA:
74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.29A 3rxhA-4wwyA:
42.3		 3rxhA-4wwyA:
74.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 12 ILE A  89
VAL A 213
ILE A 242
ILE A  47
LEU A 209
 None
 0.98A 3w67B-4wwyA:
undetectable		 3w67B-4wwyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 9 LEU A  99
ASP A 102
GLY A  56
ALA A  55
VAL A 213
 None
 1.06A 4dqcB-4wwyA:
undetectable		 4dqcB-4wwyA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 12 HIS A  57
LEU A  99
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 None
 0.62A 4hfpD-4wwyA:
33.8		 4hfpD-4wwyA:
36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 9 LEU A  99
ASP A 102
GLY A  56
ALA A  55
VAL A 213
 None
 1.06A 4njtD-4wwyA:
undetectable		 4njtD-4wwyA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 10 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.99A 4ph9A-4wwyA:
undetectable		 4ph9A-4wwyA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wwy TRYPSIN-1
(Homo
sapiens) 		5 / 10 VAL A  52
LEU A  67
ALA A  85
SER A 109
LEU A 108
 None
 0.98A 4ph9B-4wwyA:
undetectable		 4ph9B-4wwyA:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4wwy TRYPSIN-1
(Homo
sapiens) 		6 / 12 HIS A  57
LEU A  99
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.63A 4rn6B-4wwyA:
28.5		 4rn6B-4wwyA:
36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 4wwy TRYPSIN-1
(Homo
sapiens) 		4 / 7 ILE A 106
ILE A  47
THR A 241
ILE A 242
 None
 0.79A 5fukA-4wwyA:
undetectable
5fukB-4wwyA:
undetectable		 5fukA-4wwyA:
21.83
5fukB-4wwyA:
21.83