SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 118
LEU A 121
SER A 170
SER A 349
None
None
CAC  A 502 (-4.7A)
CAC  A 502 ( 4.8A)
None
1.11A 1dfoA-4wxbA:
58.5
1dfoA-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1dfoA-4wxbA:
58.5
1dfoA-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.09A 1dfoA-4wxbA:
58.5
1dfoA-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
None
0.77A 1dfoB-4wxbA:
60.3
1dfoB-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
None
0.77A 1dfoA-4wxbA:
58.5
1dfoA-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 118
LEU A 121
SER A 170
SER A 349
None
None
CAC  A 502 (-4.7A)
CAC  A 502 ( 4.8A)
None
1.11A 1dfoB-4wxbA:
60.3
1dfoB-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1dfoB-4wxbA:
60.3
1dfoB-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.09A 1dfoB-4wxbA:
60.3
1dfoB-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 118
LEU A 121
SER A 170
SER A 349
None
None
CAC  A 502 (-4.7A)
CAC  A 502 ( 4.8A)
None
1.11A 1dfoC-4wxbA:
60.3
1dfoC-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1dfoC-4wxbA:
60.3
1dfoC-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.09A 1dfoC-4wxbA:
60.3
1dfoC-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
None
0.78A 1dfoD-4wxbA:
58.5
1dfoD-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 5 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
None
0.78A 1dfoC-4wxbA:
60.3
1dfoC-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 118
LEU A 121
SER A 170
SER A 349
None
None
CAC  A 502 (-4.7A)
CAC  A 502 ( 4.8A)
None
1.11A 1dfoD-4wxbA:
58.5
1dfoD-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1dfoD-4wxbA:
58.5
1dfoD-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.09A 1dfoD-4wxbA:
58.5
1dfoD-4wxbA:
58.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1eqbA-4wxbA:
58.4
1eqbA-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.11A 1eqbA-4wxbA:
58.4
1eqbA-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
3 / 3 GLU A  51
TYR A  58
PHE A 250
None
0.72A 1eqbB-4wxbA:
60.2
1eqbB-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 8 SER A  29
SER A 170
HIS A 198
LYS A 224
ARG A 357
CAC  A 502 (-3.2A)
CAC  A 502 ( 4.8A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
0.72A 1eqbA-4wxbA:
58.4
1eqbB-4wxbA:
60.2
1eqbA-4wxbA:
58.60
1eqbB-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
3 / 3 GLU A  51
TYR A  58
PHE A 250
None
0.71A 1eqbA-4wxbA:
58.4
1eqbA-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
6 / 12 LEU A 115
GLY A 118
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
None
None
None
CAC  A 502 (-3.1A)
0.75A 1eqbB-4wxbA:
60.2
1eqbB-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
6 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
CAC  A 502 (-3.1A)
0.88A 1eqbB-4wxbA:
60.2
1eqbB-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.11A 1eqbB-4wxbA:
60.2
1eqbB-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 8 SER A  29
SER A 170
HIS A 198
LYS A 224
ARG A 357
CAC  A 502 (-3.2A)
CAC  A 502 ( 4.8A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
0.71A 1eqbA-4wxbA:
58.4
1eqbB-4wxbA:
60.2
1eqbA-4wxbA:
58.60
1eqbB-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1eqbC-4wxbA:
60.2
1eqbC-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.11A 1eqbC-4wxbA:
60.2
1eqbC-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
3 / 3 GLU A  51
TYR A  58
PHE A 250
None
0.71A 1eqbD-4wxbA:
59.0
1eqbD-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 8 SER A  29
SER A 170
HIS A 198
LYS A 224
ARG A 357
CAC  A 502 (-3.2A)
CAC  A 502 ( 4.8A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
0.72A 1eqbC-4wxbA:
60.2
1eqbD-4wxbA:
59.0
1eqbC-4wxbA:
58.60
1eqbD-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
3 / 3 GLU A  51
TYR A  58
PHE A 250
None
0.72A 1eqbC-4wxbA:
60.2
1eqbC-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
7 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 341
SER A 349
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
None
CAC  A 502 (-3.1A)
0.87A 1eqbD-4wxbA:
59.0
1eqbD-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 119
ASN A 341
SER A 349
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
1.11A 1eqbD-4wxbA:
59.0
1eqbD-4wxbA:
58.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 8 SER A  29
SER A 170
HIS A 198
LYS A 224
ARG A 357
CAC  A 502 (-3.2A)
CAC  A 502 ( 4.8A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
0.71A 1eqbC-4wxbA:
60.2
1eqbD-4wxbA:
59.0
1eqbC-4wxbA:
58.60
1eqbD-4wxbA:
58.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 4 ALA A  40
VAL A 267
ALA A 264
HIS A 260
None
1.07A 1q23A-4wxbA:
undetectable
1q23A-4wxbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 4 ALA A  40
VAL A 267
ALA A 264
HIS A 260
None
1.16A 1q23F-4wxbA:
undetectable
1q23F-4wxbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 331
LEU A 338
ILE A  24
ILE A 376
ALA A 377
None
1.00A 2bxqA-4wxbA:
undetectable
2bxqA-4wxbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 11 SER A  93
SER A  91
THR A 221
GLY A 231
HIS A 223
CIT  A 501 (-2.7A)
CIT  A 501 (-3.8A)
CIT  A 501 (-4.5A)
None
CIT  A 501 (-3.8A)
1.39A 2hmaA-4wxbA:
undetectable
2hmaA-4wxbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 8 HIS A 208
PRO A 209
SER A 173
SER A 305
None
1.18A 2obvA-4wxbA:
undetectable
2obvA-4wxbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A  26
ILE A 336
ALA A 362
THR A 404
MET A 291
None
1.18A 2qo4A-4wxbA:
undetectable
2qo4A-4wxbA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A  26
ILE A 336
ALA A 362
THR A 404
MET A 291
None
1.19A 2qo6A-4wxbA:
undetectable
2qo6A-4wxbA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 9 PHE A 277
LEU A 233
ALA A 268
LEU A 269
PHE A  80
None
1.24A 2vcvD-4wxbA:
0.8
2vcvD-4wxbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 9 PHE A 277
LEU A 233
ALA A 268
LEU A 269
PHE A  80
None
1.24A 2vcvH-4wxbA:
undetectable
2vcvH-4wxbA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 6 GLU A  51
TYR A  58
TYR A  59
PHE A 250
PRO A 251
None
0.85A 2vmyA-4wxbA:
58.1
2vmyA-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 LEU A 115
GLY A 118
ALA A 171
ASN A 341
ARG A 357
None
None
None
None
CAC  A 502 (-3.1A)
0.62A 2vmyB-4wxbA:
58.0
2vmyB-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 7 HIS A 120
HIS A 198
LYS A 224
ARG A 357
None
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
1.34A 2vmyA-4wxbA:
58.1
2vmyB-4wxbA:
58.0
2vmyA-4wxbA:
58.87
2vmyB-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 7 SER A  29
HIS A 198
LYS A 224
ARG A 357
CAC  A 502 (-3.2A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
0.37A 2vmyA-4wxbA:
58.1
2vmyB-4wxbA:
58.0
2vmyA-4wxbA:
58.87
2vmyB-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
6 / 12 LEU A 115
GLY A 118
SER A 170
ALA A 171
ASN A 339
ARG A 357
None
None
CAC  A 502 ( 4.8A)
None
None
CAC  A 502 (-3.1A)
0.83A 2vmyA-4wxbA:
58.1
2vmyA-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 4 GLU A  51
TYR A  58
TYR A  59
PHE A 250
None
0.97A 2vmyB-4wxbA:
58.0
2vmyB-4wxbA:
58.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 8 SER A  29
SER A 170
HIS A 198
LYS A 224
ARG A 357
CAC  A 502 (-3.2A)
CAC  A 502 ( 4.8A)
CAC  A 502 (-4.0A)
CIT  A 501 ( 2.8A)
CAC  A 502 (-3.1A)
0.76A 2vmyA-4wxbA:
58.1
2vmyB-4wxbA:
58.0
2vmyA-4wxbA:
58.87
2vmyB-4wxbA:
58.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 7 ASN A  86
ALA A  72
ALA A  76
GLN A  88
GOL  A 503 (-4.2A)
None
None
None
0.80A 3a2qA-4wxbA:
undetectable
3a2qA-4wxbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 7 ASN A 283
SER A 360
ALA A 289
ALA A 290
None
0.65A 3a2qA-4wxbA:
undetectable
3a2qA-4wxbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 10 ASP A 195
GLY A 231
GLY A 232
LEU A 233
VAL A  99
None
1.02A 3em4V-4wxbA:
undetectable
3em4V-4wxbA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 11 ILE A 356
GLY A 355
ASP A 316
LEU A 384
ALA A 327
None
1.17A 3kw2A-4wxbA:
undetectable
3kw2A-4wxbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 11 ILE A 356
GLY A 355
ASP A 316
LEU A 384
ALA A 327
None
1.20A 3kw2B-4wxbA:
undetectable
3kw2B-4wxbA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 7 VAL A 358
PHE A 295
VAL A 381
ILE A  24
None
0.84A 3zjqA-4wxbA:
undetectable
3zjqA-4wxbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 7 VAL A 358
PHE A 295
VAL A 381
ILE A  24
None
0.85A 3zjqB-4wxbA:
undetectable
3zjqB-4wxbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 6 ALA A 272
GLY A 228
PRO A 229
LEU A 269
None
0.99A 4dubA-4wxbA:
undetectable
4dubA-4wxbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 PHE A  80
ALA A 200
THR A 225
GLU A 271
ALA A 272
None
1.18A 4fiaA-4wxbA:
undetectable
4fiaA-4wxbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 PHE A  80
ALA A 200
THR A 225
GLU A 271
ALA A 272
None
1.18A 4fiaA-4wxbA:
undetectable
4fiaA-4wxbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 12 GLN A  88
LEU A 258
GLY A 232
ALA A 197
ASN A  96
None
1.26A 4pclB-4wxbA:
3.1
4pclB-4wxbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 9 ALA A 263
ALA A  40
ALA A  36
SER A  34
ALA A 266
None
1.27A 4twdA-4wxbA:
undetectable
4twdB-4wxbA:
undetectable
4twdC-4wxbA:
undetectable
4twdD-4wxbA:
undetectable
4twdE-4wxbA:
undetectable
4twdA-4wxbA:
21.56
4twdB-4wxbA:
21.56
4twdC-4wxbA:
21.56
4twdD-4wxbA:
21.56
4twdE-4wxbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 4 ALA A 266
VAL A  87
GLY A 232
THR A 222
None
1.14A 4ubeA-4wxbA:
undetectable
4ubeA-4wxbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
5 / 11 ASP A  66
PRO A  54
ARG A  57
GLU A 259
ALA A 268
None
1.42A 6bm5A-4wxbA:
undetectable
6bm5A-4wxbA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA502_0
(CANAVALIN)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 4 GLY A 324
LYS A 340
GLN A 328
ASN A 323
None
1.48A 6cb4A-4wxbA:
0.0
6cb4A-4wxbA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus)
4 / 8 HIS A 208
PRO A 209
SER A 173
SER A 305
None
1.20A 6fcbA-4wxbA:
undetectable
6fcbA-4wxbA:
23.14