SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 12 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.68A 1lbcA-4wxjA:
37.1
1lbcC-4wxjA:
37.0		 1lbcA-4wxjA:
40.36
1lbcC-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 9 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.72A 1lbcB-4wxjA:
37.0		 1lbcB-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 12 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.73A 1lbcA-4wxjA:
37.1
1lbcC-4wxjA:
37.0		 1lbcA-4wxjA:
40.36
1lbcC-4wxjA:
40.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 9 PHE A 109
GLY A 227
TYR A 226
ALA A 149
GLU A 200
 None
None
GLU  A 301 ( 4.6A)
GLU  A 301 (-3.0A)
GLU  A 301 (-2.1A)
 1.34A 1mrgA-4wxjA:
undetectable		 1mrgA-4wxjA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 8 GLN A 137
ASP A 127
ILE A 128
ILE A 217
 None
 0.92A 1rg9B-4wxjA:
undetectable		 1rg9B-4wxjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 12 GLY A  18
PRO A  20
ASN A 180
ASP A  65
VAL A  63
 None
 1.23A 2zzmA-4wxjA:
undetectable		 2zzmA-4wxjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 12 GLY A  18
PRO A  20
ASN A 180
ASP A  65
VAL A  63
 None
 1.30A 2zznA-4wxjA:
undetectable		 2zznA-4wxjA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 5 ASP A  79
ARG A  16
ILE A  81
THR A 150
 None
None
None
GLU  A 301 (-3.5A)
 1.19A 3eigA-4wxjA:
undetectable		 3eigA-4wxjA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 11 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.79A 3h6tA-4wxjA:
36.7
3h6tC-4wxjA:
36.4		 3h6tA-4wxjA:
40.36
3h6tC-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 9 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.75A 3h6tB-4wxjA:
36.1		 3h6tB-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 11 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.75A 3h6tA-4wxjA:
36.7
3h6tC-4wxjA:
36.4		 3h6tA-4wxjA:
40.36
3h6tC-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 12 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.62A 3iltB-4wxjA:
34.6
3iltE-4wxjA:
34.3		 3iltB-4wxjA:
41.42
3iltE-4wxjA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 10 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.62A 3iltB-4wxjA:
34.6
3iltE-4wxjA:
34.3		 3iltB-4wxjA:
41.42
3iltE-4wxjA:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 8 GLY A 222
ILE A 120
PHE A 177
PHE A 154
 None
 1.00A 3ko0B-4wxjA:
undetectable
3ko0J-4wxjA:
undetectable		 3ko0B-4wxjA:
18.46
3ko0J-4wxjA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 8 GLY A 222
ILE A 120
PHE A 177
PHE A 154
 None
 0.91A 3ko0K-4wxjA:
undetectable
3ko0S-4wxjA:
undetectable		 3ko0K-4wxjA:
18.46
3ko0S-4wxjA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 10 TYR A  42
PRO A 112
MET A 114
SER A 248
LEU A 253
 None
 0.53A 3lsfB-4wxjA:
37.3
3lsfE-4wxjA:
37.1		 3lsfB-4wxjA:
41.42
3lsfE-4wxjA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 8 TYR A  42
PRO A 112
MET A 114
SER A 248
LEU A 253
 None
 0.53A 3lsfH-4wxjA:
36.8		 3lsfH-4wxjA:
41.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 9 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.63A 3tkdA-4wxjA:
36.6		 3tkdA-4wxjA:
40.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 9 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.58A 3tkdB-4wxjA:
36.7		 3tkdB-4wxjA:
40.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 6 LEU A 256
LEU A 253
GLU A 252
MET A  49
 None
 0.88A 4ww7A-4wxjA:
undetectable		 4ww7A-4wxjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 6 TYR A  68
GLY A  18
GLU A 182
ASN A 181
 GLU  A 301 (-2.8A)
None
None
GLU  A 301 ( 3.5A)
 1.26A 4zbqA-4wxjA:
undetectable		 4zbqA-4wxjA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 12 GLY A 184
VAL A 188
GLY A 143
ALA A 176
ASP A 175
 None
 0.93A 5x7fA-4wxjA:
undetectable		 5x7fA-4wxjA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 11 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.92A 6dlzA-4wxjA:
32.2
6dlzD-4wxjA:
6.0		 6dlzA-4wxjA:
14.02
6dlzD-4wxjA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		5 / 11 PRO A 112
MET A 114
LEU A 245
SER A 248
LEU A 253
 None
 0.92A 6dm1A-4wxjA:
32.2
6dm1D-4wxjA:
31.5		 6dm1A-4wxjA:
14.02
6dm1D-4wxjA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB
(Drosophila
melanogaster) 		4 / 8 TYR A  68
ASN A  66
ASN A 180
GLU A 182
 GLU  A 301 (-2.8A)
None
None
None
 1.11A 6hzpA-4wxjA:
undetectable		 6hzpA-4wxjA:
21.03