SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		5 / 11 LEU A 147
ASP A 145
ILE A 141
HIS A 133
HIS A 137
 None
None
None
NI  A 201 ( 3.3A)
NI  A 201 ( 3.2A)
 1.30A 1s9aA-4wxlA:
undetectable		 1s9aA-4wxlA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		5 / 12 LEU A 147
ASP A 145
ILE A 141
HIS A 133
HIS A 137
 None
None
None
NI  A 201 ( 3.3A)
NI  A 201 ( 3.2A)
 1.28A 1s9aB-4wxlA:
undetectable		 1s9aB-4wxlA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		5 / 12 LEU A 147
ASP A 145
ILE A 141
HIS A 133
HIS A 137
 None
None
None
NI  A 201 ( 3.3A)
NI  A 201 ( 3.2A)
 1.20A 3hgiA-4wxlA:
undetectable		 3hgiA-4wxlA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 HIS A 133
GLU A 134
HIS A 137
 NI  A 201 ( 3.3A)
BB2  A 202 (-2.8A)
NI  A 201 ( 3.2A)
 0.17A 3kecB-4wxlA:
undetectable		 3kecB-4wxlA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		4 / 5 GLN A 132
HIS A 133
ILE A 131
ILE A  59
 None
NI  A 201 ( 3.3A)
None
None
 1.18A 5dnuA-4wxlA:
undetectable		 5dnuA-4wxlA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		4 / 5 GLN A 132
HIS A 133
ILE A 131
ILE A  59
 None
NI  A 201 ( 3.3A)
None
None
 1.10A 5dnvA-4wxlA:
undetectable		 5dnvA-4wxlA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		4 / 5 LEU A 142
CYH A  18
LEU A  55
ASP A  11
 None
 1.45A 5mafA-4wxlA:
undetectable		 5mafA-4wxlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 VAL A  52
VAL A   6
GLN A  41
 None
 0.58A 5qgjA-4wxlA:
undetectable		 5qgjA-4wxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 VAL A  52
VAL A   6
GLN A  41
 None
 0.63A 5qgmA-4wxlA:
undetectable		 5qgmA-4wxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 VAL A  52
VAL A   6
GLN A  41
 None
 0.60A 5qgnA-4wxlA:
undetectable		 5qgnA-4wxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 VAL A  52
VAL A   6
GLN A  41
 None
 0.66A 5qh5A-4wxlA:
undetectable		 5qh5A-4wxlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 VAL A  52
VAL A   6
GLN A  41
 None
 0.65A 5qh7A-4wxlA:
undetectable		 5qh7A-4wxlA:
19.60