SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4wxm TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A   9
LEU A  53
ALA A  52
TRP A  76
LEU A  73
 None
 1.37A 2oaxD-4wxmA:
undetectable		 2oaxD-4wxmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4wxm TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 11 ARG A 125
GLN A 122
LEU A 118
ALA A  21
LEU A  46
 None
 1.44A 3jwqA-4wxmA:
undetectable
3jwqD-4wxmA:
undetectable		 3jwqA-4wxmA:
17.88
3jwqD-4wxmA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4wxm TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		3 / 3 ARG A  50
GLU A  51
THR A   5
 None
 0.71A 3v4tA-4wxmA:
undetectable		 3v4tA-4wxmA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4wxm TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 118
LEU A 114
SER A  17
LEU A  20
LEU A  27
 None
 1.17A 4yiaA-4wxmA:
undetectable		 4yiaA-4wxmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4wxm TRANSCRIPTIONAL
REGULATOR FLEQ
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 118
ALA A 121
LEU A 102
ILE A  10
LEU A  84
LEU A  80
 None
 1.43A 5toaA-4wxmA:
undetectable		 5toaA-4wxmA:
20.56