SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		5 / 9 LEU A 226
ILE A 287
LEU A 274
GLY A 304
ALA A 310
 None
 1.13A 1e7aA-4wxpA:
undetectable		 1e7aA-4wxpA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 PHE A 444
VAL A 535
TRP A 532
 None
 0.76A 2cc8A-4wxpA:
undetectable		 2cc8A-4wxpA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 PHE A 444
VAL A 535
TRP A 532
 None
 0.74A 2ccbA-4wxpA:
undetectable		 2ccbA-4wxpA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 PHE A 444
VAL A 535
TRP A 532
 None
 0.74A 2vx9A-4wxpA:
undetectable		 2vx9A-4wxpA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		4 / 8 ALA A 315
ALA A 313
ILE A 287
HIS A 201
 None
 0.86A 3dtuC-4wxpA:
undetectable
3dtuD-4wxpA:
undetectable		 3dtuC-4wxpA:
21.62
3dtuD-4wxpA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		4 / 7 TRP A 582
LEU A 585
SER A 584
THR A 550
 None
 1.12A 3dzgB-4wxpA:
2.0		 3dzgB-4wxpA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		4 / 8 TYR A 218
LEU A 202
ALA A 204
SER A 208
 None
 1.11A 3rodA-4wxpA:
2.1		 3rodA-4wxpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		4 / 6 TRP A 582
LEU A 585
SER A 584
THR A 550
 None
 1.18A 3ropA-4wxpA:
2.1		 3ropA-4wxpA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		5 / 11 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.16A 4e0fA-4wxpA:
undetectable		 4e0fA-4wxpA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.77A 4k8cA-4wxpA:
undetectable		 4k8cA-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.78A 4kahA-4wxpA:
undetectable		 4kahA-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.79A 4kahB-4wxpA:
undetectable		 4kahB-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.76A 4kanA-4wxpA:
undetectable		 4kanA-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.77A 4kanB-4wxpA:
undetectable		 4kanB-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.77A 4kbeA-4wxpA:
undetectable		 4kbeA-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.81A 4kbeB-4wxpA:
undetectable		 4kbeB-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.76A 4lbgA-4wxpA:
undetectable		 4lbgA-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 SER A 294
TYR A 270
PRO A 326
 None
 0.77A 4lbgB-4wxpA:
undetectable		 4lbgB-4wxpA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		4 / 5 GLN A 434
THR A 435
THR A 430
HIS A 369
 None
 1.29A 4lvcC-4wxpA:
undetectable		 4lvcC-4wxpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		5 / 11 GLY A 281
LEU A 301
LEU A 274
PHE A 273
THR A 305
 None
 1.18A 4zmeA-4wxpA:
undetectable		 4zmeA-4wxpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		5 / 10 SER A 439
PHE A 444
ASP A 441
PRO A 442
LEU A 598
 None
 1.47A 5l1fD-4wxpA:
2.9		 5l1fD-4wxpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		4 / 6 LEU A 414
VAL A 331
PHE A 422
GLY A 420
 None
 1.00A 6hd4B-4wxpA:
undetectable		 6hd4B-4wxpA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4wxp NS3-4 PROTEASE
(Hepacivirus
C) 		3 / 3 ILE A 265
THR A 266
PRO A 215
 None
 0.45A 6ncsA-4wxpA:
undetectable		 6ncsA-4wxpA:
20.17