SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4wxt THIOREDOXIN
(Mycobacterium
avium) 		4 / 6 GLU A  54
ALA A  52
LEU A  30
THR A  10
 None
 0.84A 2roxB-4wxtA:
undetectable		 2roxB-4wxtA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4wxt THIOREDOXIN
(Mycobacterium
avium) 		4 / 8 PHE A  18
SER A  17
ALA A  24
LEU A  23
 None
 1.05A 4rkuA-4wxtA:
undetectable
4rkuJ-4wxtA:
undetectable		 4rkuA-4wxtA:
10.39
4rkuJ-4wxtA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4wxt THIOREDOXIN
(Mycobacterium
avium) 		4 / 7 PHE A  18
SER A  17
ALA A  24
LEU A  23
 None
 1.06A 4xk8A-4wxtA:
undetectable		 4xk8A-4wxtA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wxt THIOREDOXIN
(Mycobacterium
avium) 		4 / 8 VAL A  47
LEU A  48
GLY A  98
ALA A  99
 None
 0.82A 5f1aA-4wxtA:
undetectable		 5f1aA-4wxtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4wxt THIOREDOXIN
(Mycobacterium
avium) 		4 / 7 VAL A  13
ILE A  11
VAL A  31
ALA A  62
 None
 0.69A 5osrA-4wxtA:
undetectable		 5osrA-4wxtA:
17.82