SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 9 GLY A 268
ALA A 327
THR A 290
ILE A 288
GLY A 375
 None
 1.21A 1c9sQ-4wxuA:
undetectable
1c9sR-4wxuA:
undetectable		 1c9sQ-4wxuA:
14.78
1c9sR-4wxuA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 11 SER A 474
SER A 475
GLY A 326
THR A 325
GLY A 375
 None
None
NA  A 607 (-3.6A)
None
None
 1.31A 1jr1A-4wxuA:
undetectable		 1jr1A-4wxuA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 10 GLY A 268
ALA A 327
THR A 290
ILE A 288
GLY A 375
 None
 1.16A 1utdE-4wxuA:
undetectable
1utdF-4wxuA:
undetectable		 1utdE-4wxuA:
14.78
1utdF-4wxuA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 10 GLY A 268
ALA A 327
THR A 290
ILE A 288
GLY A 375
 None
 1.17A 1utdH-4wxuA:
undetectable
1utdI-4wxuA:
undetectable		 1utdH-4wxuA:
14.78
1utdI-4wxuA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 4wxu MYOCILIN
(Homo
sapiens) 		4 / 7 GLY A 292
ASP A 289
TRP A 489
ARG A 287
 None
 1.20A 3arrA-4wxuA:
undetectable		 3arrA-4wxuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 4wxu MYOCILIN
(Homo
sapiens) 		4 / 7 GLY A 292
ASP A 289
TRP A 489
ARG A 287
 None
 1.18A 3aruA-4wxuA:
undetectable		 3aruA-4wxuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 12 GLY A 326
GLN A 337
GLU A 323
TYR A 371
ASN A 428
 NA  A 607 (-3.6A)
None
None
None
CA  A 601 (-3.3A)
 1.43A 3t7sC-4wxuA:
undetectable		 3t7sC-4wxuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 12 TYR A 392
GLY A 399
ILE A 401
ASP A 396
ALA A 397
 None
 1.03A 3uj7A-4wxuA:
undetectable		 3uj7A-4wxuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4wxu MYOCILIN
(Homo
sapiens) 		4 / 5 SER A 324
ASP A 478
ASP A 384
ILE A 431
 None
NA  A 607 ( 2.3A)
None
None
 1.17A 3uj7B-4wxuA:
undetectable		 3uj7B-4wxuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 12 PRO A 370
TYR A 365
ALA A 339
GLY A 338
LEU A 322
 None
 1.46A 4oadA-4wxuA:
undetectable		 4oadA-4wxuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 9 ILE A 465
PHE A 430
LEU A 248
LEU A 486
ASP A 498
 None
 1.46A 4qopA-4wxuA:
undetectable		 4qopA-4wxuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 4wxu MYOCILIN
(Homo
sapiens) 		5 / 9 ILE A 465
PHE A 430
LEU A 248
LEU A 486
ASP A 498
 None
 1.45A 4qopB-4wxuA:
undetectable		 4qopB-4wxuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4wxu MYOCILIN
(Homo
sapiens) 		3 / 3 THR A 394
SER A 393
TYR A 392
 None
 0.70A 5jsdA-4wxuA:
undetectable		 5jsdA-4wxuA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4wxu MYOCILIN
(Homo
sapiens) 		3 / 3 THR A 394
SER A 393
TYR A 392
 None
 0.71A 5jsdB-4wxuA:
undetectable		 5jsdB-4wxuA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4wxu MYOCILIN
(Homo
sapiens) 		3 / 3 THR A 394
SER A 393
TYR A 392
 None
 0.70A 5jsdC-4wxuA:
undetectable		 5jsdC-4wxuA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4wxu MYOCILIN
(Homo
sapiens) 		3 / 3 THR A 394
SER A 393
TYR A 392
 None
 0.71A 5jseA-4wxuA:
undetectable		 5jseA-4wxuA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4wxu MYOCILIN
(Homo
sapiens) 		3 / 3 THR A 394
SER A 393
TYR A 392
 None
 0.70A 5jseB-4wxuA:
undetectable		 5jseB-4wxuA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4wxu MYOCILIN
(Homo
sapiens) 		3 / 3 THR A 394
SER A 393
TYR A 392
 None
 0.70A 5jseC-4wxuA:
undetectable		 5jseC-4wxuA:
17.40